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Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics

BACKGROUND: Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). Proof of concept studies have demonstrated efficacy of Hp in hemolysis associated with transfusion and sickle cell anemi...

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Detalles Bibliográficos
Autores principales:	Schaer, Christian A., Owczarek, Catherine, Deuel, Jeremy W., Schauer, Stefan, Baek, Jin Hyen, Yalamanoglu, Ayla, Hardy, Matthew P., Scotney, Pierre D., Schmidt, Peter M., Pelzing, Matthias, Soupourmas, Peter, Buehler, Paul W., Schaer, Dominik J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856381/ https://www.ncbi.nlm.nih.gov/pubmed/29544494 http://dx.doi.org/10.1186/s12896-018-0424-3

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