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Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA

INTRODUCTION: Detection and monitoring of circulating tumor DNA (ctDNA) is rapidly becoming a diagnostic, prognostic and predictive tool in cancer patient care. A growing number of gene targets have been identified as diagnostic or actionable, requiring the development of reliable technology that pr...

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Detalles Bibliográficos
Autores principales:	Gale, Davina, Lawson, Andrew R. J., Howarth, Karen, Madi, Mikidache, Durham, Bradley, Smalley, Sarah, Calaway, John, Blais, Shannon, Jones, Greg, Clark, James, Dimitrov, Peter, Pugh, Michelle, Woodhouse, Samuel, Epstein, Michael, Fernandez-Gonzalez, Ana, Whale, Alexandra S., Huggett, Jim F., Foy, Carole A., Jones, Gerwyn M., Raveh-Amit, Hadas, Schmitt, Karin, Devonshire, Alison, Green, Emma, Forshew, Tim, Plagnol, Vincent, Rosenfeld, Nitzan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856404/ https://www.ncbi.nlm.nih.gov/pubmed/29547634 http://dx.doi.org/10.1371/journal.pone.0194630

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