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Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root

The flow field past a prosthetic aortic valve comprises many details that indicate whether the prosthesis is functioning well or not. It is, however, not yet fully understood how an optimal flow scenario would look, i.e. which subtleties of the fluid dynamics in place are essential regarding the dur...

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Detalles Bibliográficos
Autores principales: Hasler, David, Obrist, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856406/
https://www.ncbi.nlm.nih.gov/pubmed/29547668
http://dx.doi.org/10.1371/journal.pone.0194384
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author Hasler, David
Obrist, Dominik
author_facet Hasler, David
Obrist, Dominik
author_sort Hasler, David
collection PubMed
description The flow field past a prosthetic aortic valve comprises many details that indicate whether the prosthesis is functioning well or not. It is, however, not yet fully understood how an optimal flow scenario would look, i.e. which subtleties of the fluid dynamics in place are essential regarding the durability and compatibility of a prosthetic valve. In this study, we measured and analyzed the 3D flow field in the vicinity of a bio-prosthetic heart valve in function of the aortic root size. The measurements were conducted within aortic root phantoms of different size, mounted in a custom-built hydraulic setup, which mimicked physiological flow conditions in the aorta. Tomographic particle image velocimetry was used to measure the 3D instantaneous velocity field at various instances. Several 3D fields (e.g. instantaneous and mean velocity, 3D shear rate) were analyzed and compared focusing on the impact of the aortic root size, but also in order to gain general insight in the 3D flow structure past the bio-prosthetic valve. We found that the diameter of the aortic jet relative to the diameter of the ascending aorta is the most important parameter in determining the characteristics of the flow. A large aortic cross-section, relative to the cross-section of the aortic jet, was associated with higher levels of turbulence intensity and higher retrograde flow in the ascending aorta.
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spelling pubmed-58564062018-03-28 Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root Hasler, David Obrist, Dominik PLoS One Research Article The flow field past a prosthetic aortic valve comprises many details that indicate whether the prosthesis is functioning well or not. It is, however, not yet fully understood how an optimal flow scenario would look, i.e. which subtleties of the fluid dynamics in place are essential regarding the durability and compatibility of a prosthetic valve. In this study, we measured and analyzed the 3D flow field in the vicinity of a bio-prosthetic heart valve in function of the aortic root size. The measurements were conducted within aortic root phantoms of different size, mounted in a custom-built hydraulic setup, which mimicked physiological flow conditions in the aorta. Tomographic particle image velocimetry was used to measure the 3D instantaneous velocity field at various instances. Several 3D fields (e.g. instantaneous and mean velocity, 3D shear rate) were analyzed and compared focusing on the impact of the aortic root size, but also in order to gain general insight in the 3D flow structure past the bio-prosthetic valve. We found that the diameter of the aortic jet relative to the diameter of the ascending aorta is the most important parameter in determining the characteristics of the flow. A large aortic cross-section, relative to the cross-section of the aortic jet, was associated with higher levels of turbulence intensity and higher retrograde flow in the ascending aorta. Public Library of Science 2018-03-16 /pmc/articles/PMC5856406/ /pubmed/29547668 http://dx.doi.org/10.1371/journal.pone.0194384 Text en © 2018 Hasler, Obrist http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hasler, David
Obrist, Dominik
Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root
title Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root
title_full Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root
title_fullStr Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root
title_full_unstemmed Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root
title_short Three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root
title_sort three-dimensional flow structures past a bio-prosthetic valve in an in-vitro model of the aortic root
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856406/
https://www.ncbi.nlm.nih.gov/pubmed/29547668
http://dx.doi.org/10.1371/journal.pone.0194384
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