Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucos...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Associação Brasileira de Divulgação Científica
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856439/ https://www.ncbi.nlm.nih.gov/pubmed/29513799 http://dx.doi.org/10.1590/1414-431X20177139 |
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author | Li, Jin-bo Zhang, Rui Han, Xiao Piao, Chun-li |
author_facet | Li, Jin-bo Zhang, Rui Han, Xiao Piao, Chun-li |
author_sort | Li, Jin-bo |
collection | PubMed |
description | Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body weight gain and fat accumulation in white adipocyte tissue of mice fed a high-fat diet. Furthermore, we found that ginsenosides Rg1 not only decreased fasting glucose concentration and the 2-h postprandial glucose concentration, but also improved insulin resistance and glucose intolerance in those mice. Ginsenoside Rg1 also activated the AMPK pathway in vitro and in vivo and increased plasma membrane translocation of GLUT4 in C2C12 skeletal muscle cells. In conclusion, our observations suggested that ginsenoside Rg1 inhibited dietary-induced obesity and improved obesity-related insulin resistance and glucose intolerance by activation of the AMPK pathway. |
format | Online Article Text |
id | pubmed-5856439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Associação Brasileira de Divulgação Científica |
record_format | MEDLINE/PubMed |
spelling | pubmed-58564392018-03-23 Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders Li, Jin-bo Zhang, Rui Han, Xiao Piao, Chun-li Braz J Med Biol Res Research Articles Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body weight gain and fat accumulation in white adipocyte tissue of mice fed a high-fat diet. Furthermore, we found that ginsenosides Rg1 not only decreased fasting glucose concentration and the 2-h postprandial glucose concentration, but also improved insulin resistance and glucose intolerance in those mice. Ginsenoside Rg1 also activated the AMPK pathway in vitro and in vivo and increased plasma membrane translocation of GLUT4 in C2C12 skeletal muscle cells. In conclusion, our observations suggested that ginsenoside Rg1 inhibited dietary-induced obesity and improved obesity-related insulin resistance and glucose intolerance by activation of the AMPK pathway. Associação Brasileira de Divulgação Científica 2018-03-01 /pmc/articles/PMC5856439/ /pubmed/29513799 http://dx.doi.org/10.1590/1414-431X20177139 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Li, Jin-bo Zhang, Rui Han, Xiao Piao, Chun-li Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders |
title | Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders |
title_full | Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders |
title_fullStr | Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders |
title_full_unstemmed | Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders |
title_short | Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders |
title_sort | ginsenoside rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856439/ https://www.ncbi.nlm.nih.gov/pubmed/29513799 http://dx.doi.org/10.1590/1414-431X20177139 |
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