Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema

Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is α-1 antitrypsin (AAT) deficiency. Due to the complexity of the murine locus, which includes up to six Serpina1 paralogs, no genetic animal model of the disease has been successfully genera...

Descripción completa

Detalles Bibliográficos
Autores principales: Borel, Florie, Sun, Huaming, Zieger, Marina, Cox, Andrew, Cardozo, Brynn, Li, Weiying, Oliveira, Gabriella, Davis, Airiel, Gruntman, Alisha, Flotte, Terence R., Brodsky, Michael H., Hoffman, Andrew M., Elmallah, Mai K., Mueller, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856518/
https://www.ncbi.nlm.nih.gov/pubmed/29453277
http://dx.doi.org/10.1073/pnas.1713689115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856518/
https://www.ncbi.nlm.nih.gov/pubmed/29453277
http://dx.doi.org/10.1073/pnas.1713689115

Ejemplares similares