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Inorganic phosphate, arsenate, and vanadate enhance exonuclease transcript cleavage by RNA polymerase by 2000-fold
Inorganic P(i) is involved in all major biochemical pathways. Here we describe a previously unreported activity of P(i). We show that P(i) and its structural mimics, vanadate and arsenate, enhance nascent transcript cleavage by RNA polymerase (RNAP). They engage an Mg(2+) ion in catalysis and activa...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856549/ https://www.ncbi.nlm.nih.gov/pubmed/29483274 http://dx.doi.org/10.1073/pnas.1720370115 |