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Host biotin is required for liver stage development in malaria parasites

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that is the target of several classes of herbicides. Malaria parasites contain a plant-like ACC, and this is the only protein predicted to be biotinylated in the parasite. We found that ACC is expressed in the apicoplast organelle in liver- a...

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Detalles Bibliográficos
Autores principales:	Dellibovi-Ragheb, Teegan A., Jhun, Hugo, Goodman, Christopher D., Walters, Maroya S., Ragheb, Daniel R. T., Matthews, Krista A., Rajaram, Krithika, Mishra, Satish, McFadden, Geoffrey I., Sinnis, Photini, Prigge, Sean T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856565/ https://www.ncbi.nlm.nih.gov/pubmed/29483266 http://dx.doi.org/10.1073/pnas.1800717115

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