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Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis

Aortic valve disease is a burgeoning public health problem associated with significant mortality. Loss of function mutations in NOTCH1 cause bicuspid aortic valve (BAV) and calcific aortic valve disease. Because calcific nodules manifest on the fibrosa side of the cusp in low fluidic oscillatory she...

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Detalles Bibliográficos
Autores principales:	Godby, Richard C., Munjal, Charu, Opoka, Amy M., Smith, J. Michael, Yutzey, Katherine E., Narmoneva, Daria A., Hinton, Robert B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856658/ https://www.ncbi.nlm.nih.gov/pubmed/29552567 http://dx.doi.org/10.3390/jcdd1030237

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