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Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet

Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to...

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Autores principales: Van Vrekhem, S., Vloebergh, K., Asadian, M., Vercruysse, C., Declercq, H., Van Tongel, A., De Wilde, L., De Geyter, N., Morent, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856771/
https://www.ncbi.nlm.nih.gov/pubmed/29549270
http://dx.doi.org/10.1038/s41598-018-22921-6
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author Van Vrekhem, S.
Vloebergh, K.
Asadian, M.
Vercruysse, C.
Declercq, H.
Van Tongel, A.
De Wilde, L.
De Geyter, N.
Morent, R.
author_facet Van Vrekhem, S.
Vloebergh, K.
Asadian, M.
Vercruysse, C.
Declercq, H.
Van Tongel, A.
De Wilde, L.
De Geyter, N.
Morent, R.
author_sort Van Vrekhem, S.
collection PubMed
description Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone. Previous studies have shown that this adhesion can be ameliorated by changing the surface chemistry using plasma technology. An atmospheric pressure plasma jet is used to treat UHMWPE substrates and to modify their surface chemistry. The modifications are investigated using several surface analysis techniques. The adhesion with bone cement is assessed using pull-out tests while osteoblast adhesion and proliferation is also tested making use of several cell viability assays. Additionally, the treated samples are put in simulated body fluid and the resulting calcium phosphate (CaP) deposition is evaluated as a measure of the in vitro bioactivity of the samples. The results show that the plasma modifications result in incorporation of oxygen in the surface, which leads to a significant improved adhesion to bone cement, an enhanced osteoblast proliferation and a more pronounced CaP deposition. The plasma-treated surfaces are therefore promising to act as a shoulder implant.
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spelling pubmed-58567712018-03-22 Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet Van Vrekhem, S. Vloebergh, K. Asadian, M. Vercruysse, C. Declercq, H. Van Tongel, A. De Wilde, L. De Geyter, N. Morent, R. Sci Rep Article Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone. Previous studies have shown that this adhesion can be ameliorated by changing the surface chemistry using plasma technology. An atmospheric pressure plasma jet is used to treat UHMWPE substrates and to modify their surface chemistry. The modifications are investigated using several surface analysis techniques. The adhesion with bone cement is assessed using pull-out tests while osteoblast adhesion and proliferation is also tested making use of several cell viability assays. Additionally, the treated samples are put in simulated body fluid and the resulting calcium phosphate (CaP) deposition is evaluated as a measure of the in vitro bioactivity of the samples. The results show that the plasma modifications result in incorporation of oxygen in the surface, which leads to a significant improved adhesion to bone cement, an enhanced osteoblast proliferation and a more pronounced CaP deposition. The plasma-treated surfaces are therefore promising to act as a shoulder implant. Nature Publishing Group UK 2018-03-16 /pmc/articles/PMC5856771/ /pubmed/29549270 http://dx.doi.org/10.1038/s41598-018-22921-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Van Vrekhem, S.
Vloebergh, K.
Asadian, M.
Vercruysse, C.
Declercq, H.
Van Tongel, A.
De Wilde, L.
De Geyter, N.
Morent, R.
Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet
title Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet
title_full Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet
title_fullStr Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet
title_full_unstemmed Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet
title_short Improving the surface properties of an UHMWPE shoulder implant with an atmospheric pressure plasma jet
title_sort improving the surface properties of an uhmwpe shoulder implant with an atmospheric pressure plasma jet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856771/
https://www.ncbi.nlm.nih.gov/pubmed/29549270
http://dx.doi.org/10.1038/s41598-018-22921-6
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