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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

BACKGROUND: Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21(WAF1/Cip1), showing that its chronic expression...

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Detalles Bibliográficos
Autores principales:	Galanos, Panagiotis, Pappas, George, Polyzos, Alexander, Kotsinas, Athanassios, Svolaki, Ioanna, Giakoumakis, Nickolaos N., Glytsou, Christina, Pateras, Ioannis S., Swain, Umakanta, Souliotis, Vassilis L., Georgakilas, Alexandros G., Geacintov, Nicholas, Scorrano, Luca, Lukas, Claudia, Lukas, Jiri, Livneh, Zvi, Lygerou, Zoi, Chowdhury, Dipanjan, Sørensen, Claus Storgaard, Bartek, Jiri, Gorgoulis, Vassilis G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857109/ https://www.ncbi.nlm.nih.gov/pubmed/29548335 http://dx.doi.org/10.1186/s13059-018-1401-9

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