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Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness
Asthma, accompanied by lung inflammation, bronchoconstriction, and airway hyperresponsiveness, is a significant public health burden. Here we report that G protein-coupled receptor Mrgprs are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstr...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857222/ https://www.ncbi.nlm.nih.gov/pubmed/29403029 http://dx.doi.org/10.1038/s41593-018-0074-8 |
| _version_ | 1783307436182994944 |
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| author | Han, Liang Limjunyawong, Nathachit Ru, Fei Li, Zhe Hall, Olivia J. Steele, Haley Zhu, Yuyan Wilson, Julie Mitzner, Wayne Kollarik, Marian Undem, Bradley J Canning, Brendan J Dong, Xinzhong |
| author_facet | Han, Liang Limjunyawong, Nathachit Ru, Fei Li, Zhe Hall, Olivia J. Steele, Haley Zhu, Yuyan Wilson, Julie Mitzner, Wayne Kollarik, Marian Undem, Bradley J Canning, Brendan J Dong, Xinzhong |
| author_sort | Han, Liang |
| collection | PubMed |
| description | Asthma, accompanied by lung inflammation, bronchoconstriction, and airway hyperresponsiveness, is a significant public health burden. Here we report that G protein-coupled receptor Mrgprs are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyperresponsiveness. These findings provide novel insights into the neural mechanisms underlying the pathogenesis of asthma. |
| format | Online Article Text |
| id | pubmed-5857222 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58572222018-08-05 Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness Han, Liang Limjunyawong, Nathachit Ru, Fei Li, Zhe Hall, Olivia J. Steele, Haley Zhu, Yuyan Wilson, Julie Mitzner, Wayne Kollarik, Marian Undem, Bradley J Canning, Brendan J Dong, Xinzhong Nat Neurosci Article Asthma, accompanied by lung inflammation, bronchoconstriction, and airway hyperresponsiveness, is a significant public health burden. Here we report that G protein-coupled receptor Mrgprs are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyperresponsiveness. These findings provide novel insights into the neural mechanisms underlying the pathogenesis of asthma. 2018-02-05 2018-03 /pmc/articles/PMC5857222/ /pubmed/29403029 http://dx.doi.org/10.1038/s41593-018-0074-8 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Han, Liang Limjunyawong, Nathachit Ru, Fei Li, Zhe Hall, Olivia J. Steele, Haley Zhu, Yuyan Wilson, Julie Mitzner, Wayne Kollarik, Marian Undem, Bradley J Canning, Brendan J Dong, Xinzhong Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness |
| title | Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness |
| title_full | Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness |
| title_fullStr | Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness |
| title_full_unstemmed | Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness |
| title_short | Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness |
| title_sort | mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyperresponsiveness |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857222/ https://www.ncbi.nlm.nih.gov/pubmed/29403029 http://dx.doi.org/10.1038/s41593-018-0074-8 |
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