Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects

The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature, biogenesis, and regulation of vDNA are unclear. We find that vDNA produced during RNA virus infection of Drosophila and mos...

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Detalles Bibliográficos
Autores principales: Poirier, Enzo Z., Goic, Bertsy, Tomé-Poderti, Lorena, Frangeul, Lionel, Boussier, Jérémy, Gausson, Valérie, Blanc, Hervé, Vallet, Thomas, Loyd, Hyelee, Levi, Laura I., Lanciano, Sophie, Baron, Chloé, Merkling, Sarah H., Lambrechts, Louis, Mirouze, Marie, Carpenter, Susan, Vignuzzi, Marco, Saleh, Maria-Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857290/
https://www.ncbi.nlm.nih.gov/pubmed/29503180
http://dx.doi.org/10.1016/j.chom.2018.02.001

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