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Combined Treatment With Dichloroacetic Acid and Pyruvate Reduces Hippocampal Neuronal Death After Transient Cerebral Ischemia

Transient cerebral ischemia (TCI) occurs when blood flow to the brain is ceased or dramatically reduced. TCI causes energy depletion and oxidative stress, which leads to neuronal death and cognitive impairment. Dichloroacetic acid (DCA) acts as an inhibitor of pyruvate dehydrogenase kinase (PDK). Ad...

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Detalles Bibliográficos
Autores principales:	Hong, Dae Ki, Kho, A Ra, Choi, Bo Young, Lee, Song Hee, Jeong, Jeong Hyun, Lee, Sang Hwon, Park, Kyoung-Ha, Park, Jae-Bong, Suh, Sang Won
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857568/ https://www.ncbi.nlm.nih.gov/pubmed/29593636 http://dx.doi.org/10.3389/fneur.2018.00137

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