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K(V)4.3 Expression Modulates Na(V)1.5 Sodium Current
In cardiomyocytes, the voltage-gated transient outward potassium current (I(to)) is responsible for the phase-1 repolarization of the action potential (AP). Gain-of-function mutations in KCND3, the gene encoding the I(to) carrying K(V)4.3 channel, have been associated with Brugada syndrome (BrS). Wh...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857579/ https://www.ncbi.nlm.nih.gov/pubmed/29593552 http://dx.doi.org/10.3389/fphys.2018.00178 |