Cargando…

Prevalence and factors associated with medication adherence among patients with hypertension in sub-Saharan Africa: protocol for a systematic review and meta-analysis

INTRODUCTION: Hypertension is the leading cardiovascular risk factor globally, associated with a high morbidity and mortality. The high prevalence of hypertension in sub-Saharan Africa (SSA) is associated with contrastingly low awareness, treatment and control rates. Adherence to medication remains...

Descripción completa

Detalles Bibliográficos
Autores principales: Agbor, Valirie Ndip, Takah, Noah Fongwen, Aminde, Leopold Ndemnge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857663/
https://www.ncbi.nlm.nih.gov/pubmed/29549213
http://dx.doi.org/10.1136/bmjopen-2017-020715
_version_ 1783307509653569536
author Agbor, Valirie Ndip
Takah, Noah Fongwen
Aminde, Leopold Ndemnge
author_facet Agbor, Valirie Ndip
Takah, Noah Fongwen
Aminde, Leopold Ndemnge
author_sort Agbor, Valirie Ndip
collection PubMed
description INTRODUCTION: Hypertension is the leading cardiovascular risk factor globally, associated with a high morbidity and mortality. The high prevalence of hypertension in sub-Saharan Africa (SSA) is associated with contrastingly low awareness, treatment and control rates. Adherence to medication remains a major determinant of optimal blood pressure control. This systematic review aims to determine the prevalence, and factors associated with adherence to antihypertensive pharmacotherapy among patients with hypertension in SSA. METHODS AND ANALYSIS: We will include studies published in Africa up to 31 December 2017. The following databases will be searched: PubMed, Embase, SCOPUS and Web of Science to identify potential studies without language restriction. To minimise chances of missing studies, resources specific to African literature such as WHO AFROLIB, African Index Medicus and African Journals Online will also be searched. Two reviewers will independently screen studies, extract data and critically appraise included studies for risk of bias, and a third reviewer will resolve discrepancies. A random-effects meta-analysis is planned to pool study-specific estimates to obtain a summary measure presented in Forest plots. Heterogeneity of included studies will be assessed using the χ(2) test on Cochrane’s Q statistic and quantified using I(2). Publication bias will be assessed using the Egger’s test and funnel plots. This protocol has been prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses for Protocols 2015 statement. ETHICAL AND DISSEMINATION: An ethical approval is not required for the proposed study, as it will be based on already published data. The end report will be presented at conferences and published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42017079838.
format Online
Article
Text
id pubmed-5857663
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-58576632018-03-20 Prevalence and factors associated with medication adherence among patients with hypertension in sub-Saharan Africa: protocol for a systematic review and meta-analysis Agbor, Valirie Ndip Takah, Noah Fongwen Aminde, Leopold Ndemnge BMJ Open Cardiovascular Medicine INTRODUCTION: Hypertension is the leading cardiovascular risk factor globally, associated with a high morbidity and mortality. The high prevalence of hypertension in sub-Saharan Africa (SSA) is associated with contrastingly low awareness, treatment and control rates. Adherence to medication remains a major determinant of optimal blood pressure control. This systematic review aims to determine the prevalence, and factors associated with adherence to antihypertensive pharmacotherapy among patients with hypertension in SSA. METHODS AND ANALYSIS: We will include studies published in Africa up to 31 December 2017. The following databases will be searched: PubMed, Embase, SCOPUS and Web of Science to identify potential studies without language restriction. To minimise chances of missing studies, resources specific to African literature such as WHO AFROLIB, African Index Medicus and African Journals Online will also be searched. Two reviewers will independently screen studies, extract data and critically appraise included studies for risk of bias, and a third reviewer will resolve discrepancies. A random-effects meta-analysis is planned to pool study-specific estimates to obtain a summary measure presented in Forest plots. Heterogeneity of included studies will be assessed using the χ(2) test on Cochrane’s Q statistic and quantified using I(2). Publication bias will be assessed using the Egger’s test and funnel plots. This protocol has been prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses for Protocols 2015 statement. ETHICAL AND DISSEMINATION: An ethical approval is not required for the proposed study, as it will be based on already published data. The end report will be presented at conferences and published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42017079838. BMJ Publishing Group 2018-03-16 /pmc/articles/PMC5857663/ /pubmed/29549213 http://dx.doi.org/10.1136/bmjopen-2017-020715 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Cardiovascular Medicine
Agbor, Valirie Ndip
Takah, Noah Fongwen
Aminde, Leopold Ndemnge
Prevalence and factors associated with medication adherence among patients with hypertension in sub-Saharan Africa: protocol for a systematic review and meta-analysis
title Prevalence and factors associated with medication adherence among patients with hypertension in sub-Saharan Africa: protocol for a systematic review and meta-analysis
title_full Prevalence and factors associated with medication adherence among patients with hypertension in sub-Saharan Africa: protocol for a systematic review and meta-analysis
title_fullStr Prevalence and factors associated with medication adherence among patients with hypertension in sub-Saharan Africa: protocol for a systematic review and meta-analysis
title_full_unstemmed Prevalence and factors associated with medication adherence among patients with hypertension in sub-Saharan Africa: protocol for a systematic review and meta-analysis
title_short Prevalence and factors associated with medication adherence among patients with hypertension in sub-Saharan Africa: protocol for a systematic review and meta-analysis
title_sort prevalence and factors associated with medication adherence among patients with hypertension in sub-saharan africa: protocol for a systematic review and meta-analysis
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857663/
https://www.ncbi.nlm.nih.gov/pubmed/29549213
http://dx.doi.org/10.1136/bmjopen-2017-020715
work_keys_str_mv AT agborvaliriendip prevalenceandfactorsassociatedwithmedicationadherenceamongpatientswithhypertensioninsubsaharanafricaprotocolforasystematicreviewandmetaanalysis
AT takahnoahfongwen prevalenceandfactorsassociatedwithmedicationadherenceamongpatientswithhypertensioninsubsaharanafricaprotocolforasystematicreviewandmetaanalysis
AT amindeleopoldndemnge prevalenceandfactorsassociatedwithmedicationadherenceamongpatientswithhypertensioninsubsaharanafricaprotocolforasystematicreviewandmetaanalysis