Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of nucleus pulposus cells under high magnitude compression though inhibiting the p38 MAPK pathway

Disc degeneration is correlated with mechanical load. Osteogenic protein-1 (OP-1) is potential to regenerate degenerative disc. To investigate whether OP-1 can protect against high magitude compression-induced nucleus pulposus (NP) cell apoptosis and NP matrix catabolism, and its potential mechanism...

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Detalles Bibliográficos
Autores principales: Fang, Haolin, Li, Xianzhou, Shen, Haiming, Sun, Buwei, Teng, Haijun, Li, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857901/
https://www.ncbi.nlm.nih.gov/pubmed/29440560
http://dx.doi.org/10.1042/BSR20180018

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