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Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β
Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1-dependent pro-inflammatory programmed cell death...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857903/ https://www.ncbi.nlm.nih.gov/pubmed/29440460 http://dx.doi.org/10.1042/BSR20171438 |
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author | Bai, Yunlong Sun, Xi Chu, Qun Li, Anqi Qin, Ying Li, Yanyao Yue, Er Wang, Hui Li, GuiYang Zahra, Syeda Madiha Dong, Chaorun Jiang, Yanan |
author_facet | Bai, Yunlong Sun, Xi Chu, Qun Li, Anqi Qin, Ying Li, Yanyao Yue, Er Wang, Hui Li, GuiYang Zahra, Syeda Madiha Dong, Chaorun Jiang, Yanan |
author_sort | Bai, Yunlong |
collection | PubMed |
description | Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1-dependent pro-inflammatory programmed cell death. Caspase-1 is involved in various types of diseases, including hepatic injury, cancers, and diabetes-related complications. However, the exact role of caspase-1 in cardiac hypertrophy is yet to be discovered. The present study aimed to explore the possible role of caspase-1 in pathogenesis of cardiac hypertrophy. We established cardiac hypertrophy models both in vivo and in vitro to detect the expression of caspase-1 and interleukin-1β (IL-1β). The results showed that caspase-1 and IL-1β expression levels were significantly up-regulated during cardiac hypertrophy. Subsequently, caspase-1 inhibitor was co-administered with angiotensin II (Ang II) in cardiomyocytes to observe whether it could attenuate cardiac hypertrophy. Results showed that caspase-1 attenuated the pro-hypertrophic effect of Ang II, which was related to the down-regulation of caspase-1 and IL-1β. In conclusion, our results provide a novel evidence that caspase-1 mediated pyroptosis is involved in cardiac hypertrophy, and the inhibition of caspase-1 will offer a therapeutic potential against cardiac hypertrophy. |
format | Online Article Text |
id | pubmed-5857903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58579032018-03-29 Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β Bai, Yunlong Sun, Xi Chu, Qun Li, Anqi Qin, Ying Li, Yanyao Yue, Er Wang, Hui Li, GuiYang Zahra, Syeda Madiha Dong, Chaorun Jiang, Yanan Biosci Rep Research Articles Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1-dependent pro-inflammatory programmed cell death. Caspase-1 is involved in various types of diseases, including hepatic injury, cancers, and diabetes-related complications. However, the exact role of caspase-1 in cardiac hypertrophy is yet to be discovered. The present study aimed to explore the possible role of caspase-1 in pathogenesis of cardiac hypertrophy. We established cardiac hypertrophy models both in vivo and in vitro to detect the expression of caspase-1 and interleukin-1β (IL-1β). The results showed that caspase-1 and IL-1β expression levels were significantly up-regulated during cardiac hypertrophy. Subsequently, caspase-1 inhibitor was co-administered with angiotensin II (Ang II) in cardiomyocytes to observe whether it could attenuate cardiac hypertrophy. Results showed that caspase-1 attenuated the pro-hypertrophic effect of Ang II, which was related to the down-regulation of caspase-1 and IL-1β. In conclusion, our results provide a novel evidence that caspase-1 mediated pyroptosis is involved in cardiac hypertrophy, and the inhibition of caspase-1 will offer a therapeutic potential against cardiac hypertrophy. Portland Press Ltd. 2018-03-16 /pmc/articles/PMC5857903/ /pubmed/29440460 http://dx.doi.org/10.1042/BSR20171438 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Bai, Yunlong Sun, Xi Chu, Qun Li, Anqi Qin, Ying Li, Yanyao Yue, Er Wang, Hui Li, GuiYang Zahra, Syeda Madiha Dong, Chaorun Jiang, Yanan Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β |
title | Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β |
title_full | Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β |
title_fullStr | Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β |
title_full_unstemmed | Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β |
title_short | Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β |
title_sort | caspase-1 regulates ang ii-induced cardiomyocyte hypertrophy via up-regulation of il-1β |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857903/ https://www.ncbi.nlm.nih.gov/pubmed/29440460 http://dx.doi.org/10.1042/BSR20171438 |
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