Cargando…

Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β

Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1-dependent pro-inflammatory programmed cell death...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Yunlong, Sun, Xi, Chu, Qun, Li, Anqi, Qin, Ying, Li, Yanyao, Yue, Er, Wang, Hui, Li, GuiYang, Zahra, Syeda Madiha, Dong, Chaorun, Jiang, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857903/
https://www.ncbi.nlm.nih.gov/pubmed/29440460
http://dx.doi.org/10.1042/BSR20171438
_version_ 1783307562453565440
author Bai, Yunlong
Sun, Xi
Chu, Qun
Li, Anqi
Qin, Ying
Li, Yanyao
Yue, Er
Wang, Hui
Li, GuiYang
Zahra, Syeda Madiha
Dong, Chaorun
Jiang, Yanan
author_facet Bai, Yunlong
Sun, Xi
Chu, Qun
Li, Anqi
Qin, Ying
Li, Yanyao
Yue, Er
Wang, Hui
Li, GuiYang
Zahra, Syeda Madiha
Dong, Chaorun
Jiang, Yanan
author_sort Bai, Yunlong
collection PubMed
description Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1-dependent pro-inflammatory programmed cell death. Caspase-1 is involved in various types of diseases, including hepatic injury, cancers, and diabetes-related complications. However, the exact role of caspase-1 in cardiac hypertrophy is yet to be discovered. The present study aimed to explore the possible role of caspase-1 in pathogenesis of cardiac hypertrophy. We established cardiac hypertrophy models both in vivo and in vitro to detect the expression of caspase-1 and interleukin-1β (IL-1β). The results showed that caspase-1 and IL-1β expression levels were significantly up-regulated during cardiac hypertrophy. Subsequently, caspase-1 inhibitor was co-administered with angiotensin II (Ang II) in cardiomyocytes to observe whether it could attenuate cardiac hypertrophy. Results showed that caspase-1 attenuated the pro-hypertrophic effect of Ang II, which was related to the down-regulation of caspase-1 and IL-1β. In conclusion, our results provide a novel evidence that caspase-1 mediated pyroptosis is involved in cardiac hypertrophy, and the inhibition of caspase-1 will offer a therapeutic potential against cardiac hypertrophy.
format Online
Article
Text
id pubmed-5857903
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-58579032018-03-29 Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β Bai, Yunlong Sun, Xi Chu, Qun Li, Anqi Qin, Ying Li, Yanyao Yue, Er Wang, Hui Li, GuiYang Zahra, Syeda Madiha Dong, Chaorun Jiang, Yanan Biosci Rep Research Articles Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1-dependent pro-inflammatory programmed cell death. Caspase-1 is involved in various types of diseases, including hepatic injury, cancers, and diabetes-related complications. However, the exact role of caspase-1 in cardiac hypertrophy is yet to be discovered. The present study aimed to explore the possible role of caspase-1 in pathogenesis of cardiac hypertrophy. We established cardiac hypertrophy models both in vivo and in vitro to detect the expression of caspase-1 and interleukin-1β (IL-1β). The results showed that caspase-1 and IL-1β expression levels were significantly up-regulated during cardiac hypertrophy. Subsequently, caspase-1 inhibitor was co-administered with angiotensin II (Ang II) in cardiomyocytes to observe whether it could attenuate cardiac hypertrophy. Results showed that caspase-1 attenuated the pro-hypertrophic effect of Ang II, which was related to the down-regulation of caspase-1 and IL-1β. In conclusion, our results provide a novel evidence that caspase-1 mediated pyroptosis is involved in cardiac hypertrophy, and the inhibition of caspase-1 will offer a therapeutic potential against cardiac hypertrophy. Portland Press Ltd. 2018-03-16 /pmc/articles/PMC5857903/ /pubmed/29440460 http://dx.doi.org/10.1042/BSR20171438 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Bai, Yunlong
Sun, Xi
Chu, Qun
Li, Anqi
Qin, Ying
Li, Yanyao
Yue, Er
Wang, Hui
Li, GuiYang
Zahra, Syeda Madiha
Dong, Chaorun
Jiang, Yanan
Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β
title Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β
title_full Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β
title_fullStr Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β
title_full_unstemmed Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β
title_short Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β
title_sort caspase-1 regulates ang ii-induced cardiomyocyte hypertrophy via up-regulation of il-1β
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857903/
https://www.ncbi.nlm.nih.gov/pubmed/29440460
http://dx.doi.org/10.1042/BSR20171438
work_keys_str_mv AT baiyunlong caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT sunxi caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT chuqun caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT lianqi caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT qinying caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT liyanyao caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT yueer caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT wanghui caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT liguiyang caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT zahrasyedamadiha caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT dongchaorun caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b
AT jiangyanan caspase1regulatesangiiinducedcardiomyocytehypertrophyviaupregulationofil1b