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Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection
Pre-existing antibodies can aggravate disease during subsequent infection or vaccination via the mechanism of antibody-dependent enhancement (ADE) of infection. Herein, using dengue virus (DENV) as a model, we present a versatile surface-camouflage strategy to obtain a virus core-calcium phosphate s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857936/ https://www.ncbi.nlm.nih.gov/pubmed/29568472 http://dx.doi.org/10.1039/c7sc03868b |
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author | Wang, Xiaoyu Deng, Yong-Qiang Yang, Dong Xiao, Yun Zhao, Hui Nian, Qing-Gong Xu, Xurong Li, Xiao-Feng Tang, Ruikang Qin, Cheng-Feng |
author_facet | Wang, Xiaoyu Deng, Yong-Qiang Yang, Dong Xiao, Yun Zhao, Hui Nian, Qing-Gong Xu, Xurong Li, Xiao-Feng Tang, Ruikang Qin, Cheng-Feng |
author_sort | Wang, Xiaoyu |
collection | PubMed |
description | Pre-existing antibodies can aggravate disease during subsequent infection or vaccination via the mechanism of antibody-dependent enhancement (ADE) of infection. Herein, using dengue virus (DENV) as a model, we present a versatile surface-camouflage strategy to obtain a virus core-calcium phosphate shell hybrid by self-templated biomineralization. The shelled DENV stealthily avoids recognition by pre-existing antibodies under extracellular conditions, resulting in the efficient abrogation of the ADE of infection both in vitro and in vivo. Moreover, the nanoshell can spontaneously degrade under intracellular conditions to restore the virus activity and immunogenicity due to its pH-sensitive behaviour. This work demonstrates that the biomimetic material shell can significantly improve the administration safety and potency of the DENV vaccine, which provides the promising prospect of chemically designed virus-material hybrids for immune evasion. |
format | Online Article Text |
id | pubmed-5857936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-58579362018-03-22 Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection Wang, Xiaoyu Deng, Yong-Qiang Yang, Dong Xiao, Yun Zhao, Hui Nian, Qing-Gong Xu, Xurong Li, Xiao-Feng Tang, Ruikang Qin, Cheng-Feng Chem Sci Chemistry Pre-existing antibodies can aggravate disease during subsequent infection or vaccination via the mechanism of antibody-dependent enhancement (ADE) of infection. Herein, using dengue virus (DENV) as a model, we present a versatile surface-camouflage strategy to obtain a virus core-calcium phosphate shell hybrid by self-templated biomineralization. The shelled DENV stealthily avoids recognition by pre-existing antibodies under extracellular conditions, resulting in the efficient abrogation of the ADE of infection both in vitro and in vivo. Moreover, the nanoshell can spontaneously degrade under intracellular conditions to restore the virus activity and immunogenicity due to its pH-sensitive behaviour. This work demonstrates that the biomimetic material shell can significantly improve the administration safety and potency of the DENV vaccine, which provides the promising prospect of chemically designed virus-material hybrids for immune evasion. Royal Society of Chemistry 2017-12-01 2017-10-20 /pmc/articles/PMC5857936/ /pubmed/29568472 http://dx.doi.org/10.1039/c7sc03868b Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
spellingShingle | Chemistry Wang, Xiaoyu Deng, Yong-Qiang Yang, Dong Xiao, Yun Zhao, Hui Nian, Qing-Gong Xu, Xurong Li, Xiao-Feng Tang, Ruikang Qin, Cheng-Feng Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection |
title | Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection
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title_full | Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection
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title_fullStr | Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection
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title_full_unstemmed | Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection
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title_short | Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection
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title_sort | biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857936/ https://www.ncbi.nlm.nih.gov/pubmed/29568472 http://dx.doi.org/10.1039/c7sc03868b |
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