DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages

Protein SUMOylation has been reported to play a role in innate immune response, but the enzymes, substrates, and consequences of the specific inflammatory signaling events are largely unknown. Reactive oxygen species (ROS) are abundantly produced during macrophage activation and required for Toll-li...

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Detalles Bibliográficos
Autores principales: Lao, Yimin, Yang, Kai, Wang, Zhaojun, Sun, Xueqing, Zou, Qiang, Yu, Xiaoyan, Cheng, Jinke, Tong, Xuemei, Yeh, Edward T. H., Yang, Jie, Yi, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857993/
https://www.ncbi.nlm.nih.gov/pubmed/29352108
http://dx.doi.org/10.1074/jbc.M117.816769

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