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E. coli Nissle 1917-Derived Minicells for Targeted Delivery of Chemotherapeutic Drug to Hypoxic Regions for Cancer Therapy

Purpose: Systemic administration of free chemotherapeutic drugs leads to severe toxic effects, and physiological characteristics of solid tumors restrain the drugs from reaching the hypoxic regions. E. coli Nissle 1917 (EcN) has been known to penetrate the barrier and proliferate in the interface be...

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Detalles Bibliográficos
Autores principales:	Zhang, Yunlei, Ji, Wei, He, Lian, Chen, Yiyan, Ding, Xuezhi, Sun, Yunjun, Hu, Shengbiao, Yang, Huijun, Huang, Weitao, Zhang, Youming, Liu, Fei, Xia, Liqiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858176/ https://www.ncbi.nlm.nih.gov/pubmed/29556350 http://dx.doi.org/10.7150/thno.21575

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