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GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study

Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumoni...

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Autores principales: Du, Lehui, Yu, Wei, Huang, Xiang, Zhao, Nana, Liu, Fang, tong, Fang, Zhang, Sujing, Niu, Baolong, Liu, Xiaoliang, Xu, Shouping, Huang, Yurong, Dai, Xiangkun, Xie, Chuanbin, Chen, Gaoxiang, Cong, Xiaohu, Qu, Baolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858494/
https://www.ncbi.nlm.nih.gov/pubmed/29556330
http://dx.doi.org/10.7150/jca.20643
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author Du, Lehui
Yu, Wei
Huang, Xiang
Zhao, Nana
Liu, Fang
tong, Fang
Zhang, Sujing
Niu, Baolong
Liu, Xiaoliang
Xu, Shouping
Huang, Yurong
Dai, Xiangkun
Xie, Chuanbin
Chen, Gaoxiang
Cong, Xiaohu
Qu, Baolin
author_facet Du, Lehui
Yu, Wei
Huang, Xiang
Zhao, Nana
Liu, Fang
tong, Fang
Zhang, Sujing
Niu, Baolong
Liu, Xiaoliang
Xu, Shouping
Huang, Yurong
Dai, Xiangkun
Xie, Chuanbin
Chen, Gaoxiang
Cong, Xiaohu
Qu, Baolin
author_sort Du, Lehui
collection PubMed
description Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conducted a prospective study to evaluate the associations between functional SNPs and risk of RP. Methods: We recruited a total of 149 lung cancer patients who had received intensity modulated radiation therapy (IMRT). GSTP1 and XRCC1 were genotyped using the SurPlexTM-xTAG method in all patients. RP events were prospectively scored using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4.0. Kaplan-Meier analysis was used to determine the cumulative probability of RP of grade ≥ 2. Cox proportional hazard regression was performed to identify clinical variables and SNPs associated with risk of RP grade ≥ 2, using univariate and multivariate analysis, respectively. Results: With a median follow-up of 9 months, the incidence of RP of grade ≥ 2 was 38.3%. A predicting role in RP was observed for the GSTP1 SNP (adjusted hazard ratio 3.543; 95% CI 1.770-7.092; adjusted P< 0.001 for the Ile/Val and Val/Val genotypes versus Ile/Ile genotype). Whereas, we found that patients with XRCC1 399Arg/Gln and Gln/Gln genotypes had a lower risk of RP compares with those carrying Arg/Arg genotype (adjusted HR 0.653; 95% CI 0.342-1.245), but with no statistical significance observed (adjusted P = 0.195). Conclusions: Our results suggested a novel association between GSTP1 SNP 105Ile/Val and risk of RP development, which suggests the potential use of this genetic polymorphism as a predictor of RP. In addition, genetic polymorphisms of XRCC1 399Arg/Gln may also be associated with RP.
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spelling pubmed-58584942018-03-19 GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study Du, Lehui Yu, Wei Huang, Xiang Zhao, Nana Liu, Fang tong, Fang Zhang, Sujing Niu, Baolong Liu, Xiaoliang Xu, Shouping Huang, Yurong Dai, Xiangkun Xie, Chuanbin Chen, Gaoxiang Cong, Xiaohu Qu, Baolin J Cancer Research Paper Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conducted a prospective study to evaluate the associations between functional SNPs and risk of RP. Methods: We recruited a total of 149 lung cancer patients who had received intensity modulated radiation therapy (IMRT). GSTP1 and XRCC1 were genotyped using the SurPlexTM-xTAG method in all patients. RP events were prospectively scored using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4.0. Kaplan-Meier analysis was used to determine the cumulative probability of RP of grade ≥ 2. Cox proportional hazard regression was performed to identify clinical variables and SNPs associated with risk of RP grade ≥ 2, using univariate and multivariate analysis, respectively. Results: With a median follow-up of 9 months, the incidence of RP of grade ≥ 2 was 38.3%. A predicting role in RP was observed for the GSTP1 SNP (adjusted hazard ratio 3.543; 95% CI 1.770-7.092; adjusted P< 0.001 for the Ile/Val and Val/Val genotypes versus Ile/Ile genotype). Whereas, we found that patients with XRCC1 399Arg/Gln and Gln/Gln genotypes had a lower risk of RP compares with those carrying Arg/Arg genotype (adjusted HR 0.653; 95% CI 0.342-1.245), but with no statistical significance observed (adjusted P = 0.195). Conclusions: Our results suggested a novel association between GSTP1 SNP 105Ile/Val and risk of RP development, which suggests the potential use of this genetic polymorphism as a predictor of RP. In addition, genetic polymorphisms of XRCC1 399Arg/Gln may also be associated with RP. Ivyspring International Publisher 2018-02-01 /pmc/articles/PMC5858494/ /pubmed/29556330 http://dx.doi.org/10.7150/jca.20643 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Du, Lehui
Yu, Wei
Huang, Xiang
Zhao, Nana
Liu, Fang
tong, Fang
Zhang, Sujing
Niu, Baolong
Liu, Xiaoliang
Xu, Shouping
Huang, Yurong
Dai, Xiangkun
Xie, Chuanbin
Chen, Gaoxiang
Cong, Xiaohu
Qu, Baolin
GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study
title GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study
title_full GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study
title_fullStr GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study
title_full_unstemmed GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study
title_short GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study
title_sort gstp1 ile105val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in chinese population: a prospective study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858494/
https://www.ncbi.nlm.nih.gov/pubmed/29556330
http://dx.doi.org/10.7150/jca.20643
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