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Transcriptional Regulation of Emergency Granulopoiesis in Leukemia

Neutropenic conditions are prevalent in leukemia patients and are often associated with increased susceptibility to infections. In fact, emergency granulopoiesis (EG), a process regulating neutrophil homeostasis in inflammatory conditions and infections, may occur improperly in leukemic conditions,...

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Autores principales: Hasan, Shirin, Naqvi, Afsar R., Rizvi, Asim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858521/
https://www.ncbi.nlm.nih.gov/pubmed/29593731
http://dx.doi.org/10.3389/fimmu.2018.00481
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author Hasan, Shirin
Naqvi, Afsar R.
Rizvi, Asim
author_facet Hasan, Shirin
Naqvi, Afsar R.
Rizvi, Asim
author_sort Hasan, Shirin
collection PubMed
description Neutropenic conditions are prevalent in leukemia patients and are often associated with increased susceptibility to infections. In fact, emergency granulopoiesis (EG), a process regulating neutrophil homeostasis in inflammatory conditions and infections, may occur improperly in leukemic conditions, leading to reduced neutrophil counts. Unfortunately, the mechanisms central to dysfunctional EG remain understudied in both leukemia patients and leukemic mouse models. However, despite no direct studies on EG response in leukemia are reported, recently certain transcription factors (TFs) have been found to function at the crossroads of leukemia and EG. In this review, we present an update on TFs that can potentially govern the fate of EG in leukemia. Transcriptional control of Fanconi DNA repair pathway genes is also highlighted, as well as the newly discovered role of Fanconi proteins in innate immune response and EG. Identifying the TFs regulating EG in leukemia and dissecting their underlying mechanisms may facilitate the discovery of therapeutic drugs for the treatment of neutropenia.
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spelling pubmed-58585212018-03-28 Transcriptional Regulation of Emergency Granulopoiesis in Leukemia Hasan, Shirin Naqvi, Afsar R. Rizvi, Asim Front Immunol Immunology Neutropenic conditions are prevalent in leukemia patients and are often associated with increased susceptibility to infections. In fact, emergency granulopoiesis (EG), a process regulating neutrophil homeostasis in inflammatory conditions and infections, may occur improperly in leukemic conditions, leading to reduced neutrophil counts. Unfortunately, the mechanisms central to dysfunctional EG remain understudied in both leukemia patients and leukemic mouse models. However, despite no direct studies on EG response in leukemia are reported, recently certain transcription factors (TFs) have been found to function at the crossroads of leukemia and EG. In this review, we present an update on TFs that can potentially govern the fate of EG in leukemia. Transcriptional control of Fanconi DNA repair pathway genes is also highlighted, as well as the newly discovered role of Fanconi proteins in innate immune response and EG. Identifying the TFs regulating EG in leukemia and dissecting their underlying mechanisms may facilitate the discovery of therapeutic drugs for the treatment of neutropenia. Frontiers Media S.A. 2018-03-12 /pmc/articles/PMC5858521/ /pubmed/29593731 http://dx.doi.org/10.3389/fimmu.2018.00481 Text en Copyright © 2018 Hasan, Naqvi and Rizvi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hasan, Shirin
Naqvi, Afsar R.
Rizvi, Asim
Transcriptional Regulation of Emergency Granulopoiesis in Leukemia
title Transcriptional Regulation of Emergency Granulopoiesis in Leukemia
title_full Transcriptional Regulation of Emergency Granulopoiesis in Leukemia
title_fullStr Transcriptional Regulation of Emergency Granulopoiesis in Leukemia
title_full_unstemmed Transcriptional Regulation of Emergency Granulopoiesis in Leukemia
title_short Transcriptional Regulation of Emergency Granulopoiesis in Leukemia
title_sort transcriptional regulation of emergency granulopoiesis in leukemia
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858521/
https://www.ncbi.nlm.nih.gov/pubmed/29593731
http://dx.doi.org/10.3389/fimmu.2018.00481
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