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Duchenne and Becker muscular dystrophy in adolescents: current perspectives

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are life-limiting and progressive neuromuscular conditions with significant comorbidities, many of which manifest during adolescence. BMD is a milder presentation of the condition and much less prevalent than DMD, making it less r...

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Autores principales: Andrews, Jennifer G, Wahl, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858539/
https://www.ncbi.nlm.nih.gov/pubmed/29588625
http://dx.doi.org/10.2147/AHMT.S125739
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author Andrews, Jennifer G
Wahl, Richard A
author_facet Andrews, Jennifer G
Wahl, Richard A
author_sort Andrews, Jennifer G
collection PubMed
description Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are life-limiting and progressive neuromuscular conditions with significant comorbidities, many of which manifest during adolescence. BMD is a milder presentation of the condition and much less prevalent than DMD, making it less represented in the literature, or more severely affected individuals with BMD may be subsumed into the DMD population using clinical cutoffs. Numerous consensus documents have been published on the clinical management of DMD, the most recent of which was released in 2010. The advent of these clinical management consensus papers, particularly respiratory care, has significantly increased the life span for these individuals, and the adolescent years are now a point of transition into adult lives, rather than a period of end of life. This review outlines the literature on DMD and BMD during adolescence, focusing on clinical presentation during adolescence, impact of living with a chronic illness on adolescents, and the effect that adolescents have on their chronic illness. In addition, we describe the role that palliative-care specialists could have in improving outcomes for these individuals. The increasing proportion of individuals with DMD and BMD living into adulthood underscores the need for more research into interventions and intracacies of adolescence that can improve the social aspects of their lives.
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spelling pubmed-58585392018-03-27 Duchenne and Becker muscular dystrophy in adolescents: current perspectives Andrews, Jennifer G Wahl, Richard A Adolesc Health Med Ther Review Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are life-limiting and progressive neuromuscular conditions with significant comorbidities, many of which manifest during adolescence. BMD is a milder presentation of the condition and much less prevalent than DMD, making it less represented in the literature, or more severely affected individuals with BMD may be subsumed into the DMD population using clinical cutoffs. Numerous consensus documents have been published on the clinical management of DMD, the most recent of which was released in 2010. The advent of these clinical management consensus papers, particularly respiratory care, has significantly increased the life span for these individuals, and the adolescent years are now a point of transition into adult lives, rather than a period of end of life. This review outlines the literature on DMD and BMD during adolescence, focusing on clinical presentation during adolescence, impact of living with a chronic illness on adolescents, and the effect that adolescents have on their chronic illness. In addition, we describe the role that palliative-care specialists could have in improving outcomes for these individuals. The increasing proportion of individuals with DMD and BMD living into adulthood underscores the need for more research into interventions and intracacies of adolescence that can improve the social aspects of their lives. Dove Medical Press 2018-03-15 /pmc/articles/PMC5858539/ /pubmed/29588625 http://dx.doi.org/10.2147/AHMT.S125739 Text en © 2018 Andrews and Wahl. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Andrews, Jennifer G
Wahl, Richard A
Duchenne and Becker muscular dystrophy in adolescents: current perspectives
title Duchenne and Becker muscular dystrophy in adolescents: current perspectives
title_full Duchenne and Becker muscular dystrophy in adolescents: current perspectives
title_fullStr Duchenne and Becker muscular dystrophy in adolescents: current perspectives
title_full_unstemmed Duchenne and Becker muscular dystrophy in adolescents: current perspectives
title_short Duchenne and Becker muscular dystrophy in adolescents: current perspectives
title_sort duchenne and becker muscular dystrophy in adolescents: current perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858539/
https://www.ncbi.nlm.nih.gov/pubmed/29588625
http://dx.doi.org/10.2147/AHMT.S125739
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