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Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature

Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the USA. DILI can be broadly classified as Intrinsic and Idiosyncratic. Identifying predictors and at-risk patients are challenging but can have a substantial clinical implication. This case report series demonstrate...

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Detalles Bibliográficos
Autores principales: Gayam, Vijay, Khalid, Mazin, Shrestha, Binav, Hossain, Muhammad Rajib, Dahal, Sumit, Garlapati, Pavani, Gill, Arshpal, Mandal, Amrendra Kumar, Sangha, Ruby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858623/
https://www.ncbi.nlm.nih.gov/pubmed/29568780
http://dx.doi.org/10.1177/2324709618761754
Descripción
Sumario:Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the USA. DILI can be broadly classified as Intrinsic and Idiosyncratic. Identifying predictors and at-risk patients are challenging but can have a substantial clinical implication. This case report series demonstrates the importance of valproic acid, fluconazole, and amiodarone as potential hepatoxic agents of drug-induced liver injury leading to acute hepatic failure. The causality in all cases was established by Roussel Uclaf Causality Assessment Method/Council for International Organizations of Medical Sciences score and Naranjo Algorithm. Obesity, hypo-perfusion state, and concurrent hepatotoxic agent might identify at-risk patients. Further studies are required to understand the risk factors.