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Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature
Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the USA. DILI can be broadly classified as Intrinsic and Idiosyncratic. Identifying predictors and at-risk patients are challenging but can have a substantial clinical implication. This case report series demonstrate...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858623/ https://www.ncbi.nlm.nih.gov/pubmed/29568780 http://dx.doi.org/10.1177/2324709618761754 |
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author | Gayam, Vijay Khalid, Mazin Shrestha, Binav Hossain, Muhammad Rajib Dahal, Sumit Garlapati, Pavani Gill, Arshpal Mandal, Amrendra Kumar Sangha, Ruby |
author_facet | Gayam, Vijay Khalid, Mazin Shrestha, Binav Hossain, Muhammad Rajib Dahal, Sumit Garlapati, Pavani Gill, Arshpal Mandal, Amrendra Kumar Sangha, Ruby |
author_sort | Gayam, Vijay |
collection | PubMed |
description | Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the USA. DILI can be broadly classified as Intrinsic and Idiosyncratic. Identifying predictors and at-risk patients are challenging but can have a substantial clinical implication. This case report series demonstrates the importance of valproic acid, fluconazole, and amiodarone as potential hepatoxic agents of drug-induced liver injury leading to acute hepatic failure. The causality in all cases was established by Roussel Uclaf Causality Assessment Method/Council for International Organizations of Medical Sciences score and Naranjo Algorithm. Obesity, hypo-perfusion state, and concurrent hepatotoxic agent might identify at-risk patients. Further studies are required to understand the risk factors. |
format | Online Article Text |
id | pubmed-5858623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-58586232018-03-22 Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature Gayam, Vijay Khalid, Mazin Shrestha, Binav Hossain, Muhammad Rajib Dahal, Sumit Garlapati, Pavani Gill, Arshpal Mandal, Amrendra Kumar Sangha, Ruby J Investig Med High Impact Case Rep Case Report Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the USA. DILI can be broadly classified as Intrinsic and Idiosyncratic. Identifying predictors and at-risk patients are challenging but can have a substantial clinical implication. This case report series demonstrates the importance of valproic acid, fluconazole, and amiodarone as potential hepatoxic agents of drug-induced liver injury leading to acute hepatic failure. The causality in all cases was established by Roussel Uclaf Causality Assessment Method/Council for International Organizations of Medical Sciences score and Naranjo Algorithm. Obesity, hypo-perfusion state, and concurrent hepatotoxic agent might identify at-risk patients. Further studies are required to understand the risk factors. SAGE Publications 2018-03-14 /pmc/articles/PMC5858623/ /pubmed/29568780 http://dx.doi.org/10.1177/2324709618761754 Text en © 2018 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Gayam, Vijay Khalid, Mazin Shrestha, Binav Hossain, Muhammad Rajib Dahal, Sumit Garlapati, Pavani Gill, Arshpal Mandal, Amrendra Kumar Sangha, Ruby Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature |
title | Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature |
title_full | Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature |
title_fullStr | Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature |
title_full_unstemmed | Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature |
title_short | Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature |
title_sort | drug-induced liver injury: an institutional case series and review of literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858623/ https://www.ncbi.nlm.nih.gov/pubmed/29568780 http://dx.doi.org/10.1177/2324709618761754 |
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