Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis

Immune-compromised mouse models allow for testing the preclinical efficacy of human cell transplantations and gene therapy strategies before moving forward to clinical trials. However, CRISPR/Cas9 gene editing of the W(sh)/W(sh) mouse strain to create an immune-compromised model lacking function of...

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Detalles Bibliográficos
Autores principales: Bakthavatchalu, Vasudevan, Wert, Katherine J., Feng, Yan, Mannion, Anthony, Ge, Zhongming, Garcia, Alexis, Scott, Kathleen E., Caron, Tyler J., Madden, Carolyn M., Jacobsen, Johanne T., Victora, Gabriel, Jaenisch, Rudolf, Fox, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858775/
https://www.ncbi.nlm.nih.gov/pubmed/29554148
http://dx.doi.org/10.1371/journal.pone.0194443

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