Midazolam activates caspase, MAPKs and endoplasmic reticulum stress pathways, and inhibits cell cycle and Akt pathway, to induce apoptosis in TM3 mouse Leydig progenitor cells

BACKGROUND: Midazolam (MDZ) has powerful hypnosis, amnesia, anti-anxiety and anticonvulsant effects. Studies have shown that prenatally developmental toxicity of diazepam can be observed in many organs/tissues. However, it remains elusive in male reproductive system. MATERIALS AND METHODS: TM3 mouse...

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Detalles Bibliográficos
Autores principales: Kang, Fu-Chi, Wang, Shu-Chun, Chang, Ming-Min, Pan, Bo-Syong, Wong, Kar-Lok, Cheng, Ka-Shun, So, Edmund Cheung, Huang, Bu-Miin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858853/
https://www.ncbi.nlm.nih.gov/pubmed/29588601
http://dx.doi.org/10.2147/OTT.S154442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858853/
https://www.ncbi.nlm.nih.gov/pubmed/29588601
http://dx.doi.org/10.2147/OTT.S154442

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