Delta-like 3 is silenced by HBx via histone acetylation in HBV-associated HCCs

Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. We previously showed that expression of Delta-like 3 (DLL3), a member of the family of Delta/Serrate/Lag2 ligands for the Notch receptor, is silenced by aberrant DNA methylation and that overexpression of DLL3 in an HCC...

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Detalles Bibliográficos
Autores principales: Hamamoto, Hiroki, Maemura, Kentaro, Matsuo, Kentaro, Taniguchi, Kohei, Tanaka, Yoshihisa, Futaki, Sugiko, Takeshita, Atsushi, Asai, Akira, Hayashi, Michihiro, Hirose, Yoshinobu, Kondo, Yoichi, Uchiyama, Kazuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859037/
https://www.ncbi.nlm.nih.gov/pubmed/29555949
http://dx.doi.org/10.1038/s41598-018-23318-1

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