Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage

This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20–50 mL) were enrolled. The...

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Autores principales: Kwon, Sae Min, Choi, Kyu-Sun, Yi, Hyeong-Joong, Ko, Yong, Kim, Young-Soo, Bak, Koang-Hum, Chun, Hyoung-Joon, Lee, Young-Jun, Lee, Ji Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859038/
https://www.ncbi.nlm.nih.gov/pubmed/29555930
http://dx.doi.org/10.1038/s41598-018-22916-3
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author Kwon, Sae Min
Choi, Kyu-Sun
Yi, Hyeong-Joong
Ko, Yong
Kim, Young-Soo
Bak, Koang-Hum
Chun, Hyoung-Joon
Lee, Young-Jun
Lee, Ji Young
author_facet Kwon, Sae Min
Choi, Kyu-Sun
Yi, Hyeong-Joong
Ko, Yong
Kim, Young-Soo
Bak, Koang-Hum
Chun, Hyoung-Joon
Lee, Young-Jun
Lee, Ji Young
author_sort Kwon, Sae Min
collection PubMed
description This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20–50 mL) were enrolled. The intercaudate distance (ICD) and sylvian fissure ratio (SFR) were used as linear brain atrophy parameters. The patients were divided into groups with favorable and unfavorable outcomes, according to the Glasgow Outcome Scale score, 90 days after symptom onset. Demographic and radiographic features, including the ICD and SFR, were compared between the two groups. Among the 124 patients, 74 (59.7%) exhibited a favorable outcome. The ICD and SFR values were significantly greater for the favorable group than for the unfavorable group. Multivariate analysis indicated that young age, high Glasgow Coma Scale score at admission, small hematoma volume, and increased ICD (odds ratio [OR], 1.207; 95% confidence interval [CI], 1.004–1.451) and SFR (OR, 1.046; 95% CI, 1.007–1.086, per 0.001) values had a beneficial effect on functional outcome. In conclusion, brain atrophy exhibits protective effects in patients with moderate-volume basal ganglia hemorrhage, and is an important factor for predicting functional outcome.
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spelling pubmed-58590382018-03-20 Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage Kwon, Sae Min Choi, Kyu-Sun Yi, Hyeong-Joong Ko, Yong Kim, Young-Soo Bak, Koang-Hum Chun, Hyoung-Joon Lee, Young-Jun Lee, Ji Young Sci Rep Article This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20–50 mL) were enrolled. The intercaudate distance (ICD) and sylvian fissure ratio (SFR) were used as linear brain atrophy parameters. The patients were divided into groups with favorable and unfavorable outcomes, according to the Glasgow Outcome Scale score, 90 days after symptom onset. Demographic and radiographic features, including the ICD and SFR, were compared between the two groups. Among the 124 patients, 74 (59.7%) exhibited a favorable outcome. The ICD and SFR values were significantly greater for the favorable group than for the unfavorable group. Multivariate analysis indicated that young age, high Glasgow Coma Scale score at admission, small hematoma volume, and increased ICD (odds ratio [OR], 1.207; 95% confidence interval [CI], 1.004–1.451) and SFR (OR, 1.046; 95% CI, 1.007–1.086, per 0.001) values had a beneficial effect on functional outcome. In conclusion, brain atrophy exhibits protective effects in patients with moderate-volume basal ganglia hemorrhage, and is an important factor for predicting functional outcome. Nature Publishing Group UK 2018-03-19 /pmc/articles/PMC5859038/ /pubmed/29555930 http://dx.doi.org/10.1038/s41598-018-22916-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kwon, Sae Min
Choi, Kyu-Sun
Yi, Hyeong-Joong
Ko, Yong
Kim, Young-Soo
Bak, Koang-Hum
Chun, Hyoung-Joon
Lee, Young-Jun
Lee, Ji Young
Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage
title Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage
title_full Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage
title_fullStr Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage
title_full_unstemmed Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage
title_short Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage
title_sort impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859038/
https://www.ncbi.nlm.nih.gov/pubmed/29555930
http://dx.doi.org/10.1038/s41598-018-22916-3
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