Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage
This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20–50 mL) were enrolled. The...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859038/ https://www.ncbi.nlm.nih.gov/pubmed/29555930 http://dx.doi.org/10.1038/s41598-018-22916-3 |
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author | Kwon, Sae Min Choi, Kyu-Sun Yi, Hyeong-Joong Ko, Yong Kim, Young-Soo Bak, Koang-Hum Chun, Hyoung-Joon Lee, Young-Jun Lee, Ji Young |
author_facet | Kwon, Sae Min Choi, Kyu-Sun Yi, Hyeong-Joong Ko, Yong Kim, Young-Soo Bak, Koang-Hum Chun, Hyoung-Joon Lee, Young-Jun Lee, Ji Young |
author_sort | Kwon, Sae Min |
collection | PubMed |
description | This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20–50 mL) were enrolled. The intercaudate distance (ICD) and sylvian fissure ratio (SFR) were used as linear brain atrophy parameters. The patients were divided into groups with favorable and unfavorable outcomes, according to the Glasgow Outcome Scale score, 90 days after symptom onset. Demographic and radiographic features, including the ICD and SFR, were compared between the two groups. Among the 124 patients, 74 (59.7%) exhibited a favorable outcome. The ICD and SFR values were significantly greater for the favorable group than for the unfavorable group. Multivariate analysis indicated that young age, high Glasgow Coma Scale score at admission, small hematoma volume, and increased ICD (odds ratio [OR], 1.207; 95% confidence interval [CI], 1.004–1.451) and SFR (OR, 1.046; 95% CI, 1.007–1.086, per 0.001) values had a beneficial effect on functional outcome. In conclusion, brain atrophy exhibits protective effects in patients with moderate-volume basal ganglia hemorrhage, and is an important factor for predicting functional outcome. |
format | Online Article Text |
id | pubmed-5859038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58590382018-03-20 Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage Kwon, Sae Min Choi, Kyu-Sun Yi, Hyeong-Joong Ko, Yong Kim, Young-Soo Bak, Koang-Hum Chun, Hyoung-Joon Lee, Young-Jun Lee, Ji Young Sci Rep Article This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20–50 mL) were enrolled. The intercaudate distance (ICD) and sylvian fissure ratio (SFR) were used as linear brain atrophy parameters. The patients were divided into groups with favorable and unfavorable outcomes, according to the Glasgow Outcome Scale score, 90 days after symptom onset. Demographic and radiographic features, including the ICD and SFR, were compared between the two groups. Among the 124 patients, 74 (59.7%) exhibited a favorable outcome. The ICD and SFR values were significantly greater for the favorable group than for the unfavorable group. Multivariate analysis indicated that young age, high Glasgow Coma Scale score at admission, small hematoma volume, and increased ICD (odds ratio [OR], 1.207; 95% confidence interval [CI], 1.004–1.451) and SFR (OR, 1.046; 95% CI, 1.007–1.086, per 0.001) values had a beneficial effect on functional outcome. In conclusion, brain atrophy exhibits protective effects in patients with moderate-volume basal ganglia hemorrhage, and is an important factor for predicting functional outcome. Nature Publishing Group UK 2018-03-19 /pmc/articles/PMC5859038/ /pubmed/29555930 http://dx.doi.org/10.1038/s41598-018-22916-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kwon, Sae Min Choi, Kyu-Sun Yi, Hyeong-Joong Ko, Yong Kim, Young-Soo Bak, Koang-Hum Chun, Hyoung-Joon Lee, Young-Jun Lee, Ji Young Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage |
title | Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage |
title_full | Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage |
title_fullStr | Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage |
title_full_unstemmed | Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage |
title_short | Impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage |
title_sort | impact of brain atrophy on 90-day functional outcome after moderate-volume basal ganglia hemorrhage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859038/ https://www.ncbi.nlm.nih.gov/pubmed/29555930 http://dx.doi.org/10.1038/s41598-018-22916-3 |
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