Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells

Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in mel...

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Autores principales: Seo, Jae Ok, Yumnam, Silvia, Jeong, Kwang Won, Kim, Sun Yeou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pharmaceutical Society of Korea 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859039/
https://www.ncbi.nlm.nih.gov/pubmed/29397551
http://dx.doi.org/10.1007/s12272-018-1002-x
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author Seo, Jae Ok
Yumnam, Silvia
Jeong, Kwang Won
Kim, Sun Yeou
author_facet Seo, Jae Ok
Yumnam, Silvia
Jeong, Kwang Won
Kim, Sun Yeou
author_sort Seo, Jae Ok
collection PubMed
description Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin 1 receptor) protein expression was also inhibited by finasteride thereby decreasing the expression of adenylate cyclase, MITF (Melanogenesis associated transcription factor), tyrosinases, TRP (tyrosinase-related protein) -1 and -2. Thus our study suggest that finasteride inhibits melanogenesis in melanocyte and melanoma cells by inhibiting MC1R.
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spelling pubmed-58590392018-03-22 Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells Seo, Jae Ok Yumnam, Silvia Jeong, Kwang Won Kim, Sun Yeou Arch Pharm Res Research Article Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin 1 receptor) protein expression was also inhibited by finasteride thereby decreasing the expression of adenylate cyclase, MITF (Melanogenesis associated transcription factor), tyrosinases, TRP (tyrosinase-related protein) -1 and -2. Thus our study suggest that finasteride inhibits melanogenesis in melanocyte and melanoma cells by inhibiting MC1R. Pharmaceutical Society of Korea 2018-02-03 2018 /pmc/articles/PMC5859039/ /pubmed/29397551 http://dx.doi.org/10.1007/s12272-018-1002-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Seo, Jae Ok
Yumnam, Silvia
Jeong, Kwang Won
Kim, Sun Yeou
Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
title Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
title_full Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
title_fullStr Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
title_full_unstemmed Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
title_short Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
title_sort finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859039/
https://www.ncbi.nlm.nih.gov/pubmed/29397551
http://dx.doi.org/10.1007/s12272-018-1002-x
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AT jeongkwangwon finasterideinhibitsmelanogenesisthroughregulationoftheadenylatecyclaseinmelanocytesandmelanomacells
AT kimsunyeou finasterideinhibitsmelanogenesisthroughregulationoftheadenylatecyclaseinmelanocytesandmelanomacells

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