The molecular biology of pelvi-ureteric junction obstruction

Over recent years routine ultrasound scanning has identified increasing numbers of neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This patient group presents a diagnostic and management challenge for paediatric nephrologists and urologists. In this review we consid...

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Detalles Bibliográficos
Autores principales: Jackson, Laura, Woodward, Mark, Coward, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859056/
https://www.ncbi.nlm.nih.gov/pubmed/28286898
http://dx.doi.org/10.1007/s00467-017-3629-0
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author Jackson, Laura
Woodward, Mark
Coward, Richard J.
author_facet Jackson, Laura
Woodward, Mark
Coward, Richard J.
author_sort Jackson, Laura
collection PubMed
description Over recent years routine ultrasound scanning has identified increasing numbers of neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This patient group presents a diagnostic and management challenge for paediatric nephrologists and urologists. In this review we consider the known molecular mechanisms underpinning PUJO and review the potential of utilising this information to develop novel therapeutics and diagnostic biomarkers to improve the care of children with this disorder.
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spelling pubmed-58590562018-03-22 The molecular biology of pelvi-ureteric junction obstruction Jackson, Laura Woodward, Mark Coward, Richard J. Pediatr Nephrol Review Over recent years routine ultrasound scanning has identified increasing numbers of neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This patient group presents a diagnostic and management challenge for paediatric nephrologists and urologists. In this review we consider the known molecular mechanisms underpinning PUJO and review the potential of utilising this information to develop novel therapeutics and diagnostic biomarkers to improve the care of children with this disorder. Springer Berlin Heidelberg 2017-03-13 2018 /pmc/articles/PMC5859056/ /pubmed/28286898 http://dx.doi.org/10.1007/s00467-017-3629-0 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Jackson, Laura
Woodward, Mark
Coward, Richard J.
The molecular biology of pelvi-ureteric junction obstruction
title The molecular biology of pelvi-ureteric junction obstruction
title_full The molecular biology of pelvi-ureteric junction obstruction
title_fullStr The molecular biology of pelvi-ureteric junction obstruction
title_full_unstemmed The molecular biology of pelvi-ureteric junction obstruction
title_short The molecular biology of pelvi-ureteric junction obstruction
title_sort molecular biology of pelvi-ureteric junction obstruction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859056/
https://www.ncbi.nlm.nih.gov/pubmed/28286898
http://dx.doi.org/10.1007/s00467-017-3629-0
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