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Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice

H5N6 avian influenza viruses (AIVs) can cause severe pneumonia and death in humans. However, the molecular determinants of H5N6 influenza virus mammalian adaption are still unclear. Three amino acid substitutions (HA A150V, PA A343T, PB2 E627K) are observed in H5N6 virus A/duck/Zhejiang/6D2/2013 (6D...

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Detalles Bibliográficos
Autores principales:	Peng, Xiuming, Liu, Fumin, Wu, Haibo, Peng, Xiaorong, Xu, Yufan, Wang, Liyan, Chen, Bin, Sun, Tao, Yang, Fan, Ji, Shujing, Wu, Nanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859062/ https://www.ncbi.nlm.nih.gov/pubmed/29593694 http://dx.doi.org/10.3389/fmicb.2018.00453

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