Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis

Tick saliva is a rich source of modulators of vascular biology. We have characterized Ixonnexin, a member of the “Basic-tail” family of salivary proteins from the tick Ixodes scapularis. Ixonnexin is a 104 residues (11.8 KDa), non-enzymatic basic protein which contains 3 disulfide bonds and a C-term...

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Detalles Bibliográficos
Autores principales: Assumpção, Teresa C., Mizurini, Daniella M., Ma, Dongying, Monteiro, Robson Q., Ahlstedt, Sydney, Reyes, Morayma, Kotsyfakis, Michail, Mather, Thomas N., Andersen, John F., Lukszo, Jan, Ribeiro, José M. C., Francischetti, Ivo M. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859130/
https://www.ncbi.nlm.nih.gov/pubmed/29555911
http://dx.doi.org/10.1038/s41598-018-22780-1

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