Alternative Splicing of FOXP3—Virtue and Vice

FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alt...

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Detalles Bibliográficos
Autor principal: Mailer, Reiner K. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859138/
https://www.ncbi.nlm.nih.gov/pubmed/29593749
http://dx.doi.org/10.3389/fimmu.2018.00530
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author Mailer, Reiner K. W.
author_facet Mailer, Reiner K. W.
author_sort Mailer, Reiner K. W.
collection PubMed
description FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.
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spelling pubmed-58591382018-03-28 Alternative Splicing of FOXP3—Virtue and Vice Mailer, Reiner K. W. Front Immunol Immunology FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed. Frontiers Media S.A. 2018-03-13 /pmc/articles/PMC5859138/ /pubmed/29593749 http://dx.doi.org/10.3389/fimmu.2018.00530 Text en Copyright © 2018 Mailer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Mailer, Reiner K. W.
Alternative Splicing of FOXP3—Virtue and Vice
title Alternative Splicing of FOXP3—Virtue and Vice
title_full Alternative Splicing of FOXP3—Virtue and Vice
title_fullStr Alternative Splicing of FOXP3—Virtue and Vice
title_full_unstemmed Alternative Splicing of FOXP3—Virtue and Vice
title_short Alternative Splicing of FOXP3—Virtue and Vice
title_sort alternative splicing of foxp3—virtue and vice
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859138/
https://www.ncbi.nlm.nih.gov/pubmed/29593749
http://dx.doi.org/10.3389/fimmu.2018.00530
work_keys_str_mv AT mailerreinerkw alternativesplicingoffoxp3virtueandvice

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