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Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake

Caffeine is an adenosine receptor antagonist and a possible cause of inadequate stress perfusion. Splenic switch-off (SSO) and splenic rest-stress T1-mapping have been proposed as indicators of stress adequacy during perfusion cardiac magnetic resonance (CMR). We compared myocardial rest-stress T1-m...

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Autores principales: Kuijpers, Dirkjan, van Dijk, Randy, van Assen, Marly, Kaandorp, Theodorus A. M., van Dijkman, Paul R. M., Vliegenthart, Rozemarijn, van der Harst, Pim, Oudkerk, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859139/
https://www.ncbi.nlm.nih.gov/pubmed/29177579
http://dx.doi.org/10.1007/s10554-017-1274-0
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author Kuijpers, Dirkjan
van Dijk, Randy
van Assen, Marly
Kaandorp, Theodorus A. M.
van Dijkman, Paul R. M.
Vliegenthart, Rozemarijn
van der Harst, Pim
Oudkerk, Matthijs
author_facet Kuijpers, Dirkjan
van Dijk, Randy
van Assen, Marly
Kaandorp, Theodorus A. M.
van Dijkman, Paul R. M.
Vliegenthart, Rozemarijn
van der Harst, Pim
Oudkerk, Matthijs
author_sort Kuijpers, Dirkjan
collection PubMed
description Caffeine is an adenosine receptor antagonist and a possible cause of inadequate stress perfusion. Splenic switch-off (SSO) and splenic rest-stress T1-mapping have been proposed as indicators of stress adequacy during perfusion cardiac magnetic resonance (CMR). We compared myocardial rest-stress T1-mapping with SSO and splenic rest-stress T1-mapping in patients with and without recent coffee intake. We analyzed 344 consecutive patients suspected of myocardial ischemia with adenosine perfusion CMR. All 146 normal CMR studies with a normal T1-rest of the myocardium, used as standard of reference, were included and divided in two groups. 22 patients accidentally ingested coffee < 4 h before CMR, compared to control group of 124 patients without self-reported coffee intake. Two independent readers graded SSO visually. T1-reactivity (ΔT1) was defined as percentual difference in T1-rest and T1-stress. Follow-up data were extracted from electronic patients records. In patients with recent coffee intake SSO was identified in 96%, which showed no significant difference with SSO in controls (94%, p = 0.835), however event rates were significantly different (13.6 and 0.8%, respectively (p < 0.001), median FU 17 months). Myocardial ΔT1 in the coffee group (− 5.2%) was significantly lower compared to control (+ 4.0%, p < 0.001), in contrast to the splenic ΔT1 (− 3.7 and − 4.0%, p = 0.789). The splenic T1-mapping results failed to predict false negative results. SSO and splenic rest-stress T1-mapping are not reliable indicators of stress adequacy in patients with recent coffee intake. Therefore, the dark spleen sign does not indicate adequate myocardial stress in patients with recent caffeine intake. Myocardial rest-stress T1-mapping is an excellent indicator of stress adequacy during adenosine perfusion CMR.
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spelling pubmed-58591392018-03-22 Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake Kuijpers, Dirkjan van Dijk, Randy van Assen, Marly Kaandorp, Theodorus A. M. van Dijkman, Paul R. M. Vliegenthart, Rozemarijn van der Harst, Pim Oudkerk, Matthijs Int J Cardiovasc Imaging Original Paper Caffeine is an adenosine receptor antagonist and a possible cause of inadequate stress perfusion. Splenic switch-off (SSO) and splenic rest-stress T1-mapping have been proposed as indicators of stress adequacy during perfusion cardiac magnetic resonance (CMR). We compared myocardial rest-stress T1-mapping with SSO and splenic rest-stress T1-mapping in patients with and without recent coffee intake. We analyzed 344 consecutive patients suspected of myocardial ischemia with adenosine perfusion CMR. All 146 normal CMR studies with a normal T1-rest of the myocardium, used as standard of reference, were included and divided in two groups. 22 patients accidentally ingested coffee < 4 h before CMR, compared to control group of 124 patients without self-reported coffee intake. Two independent readers graded SSO visually. T1-reactivity (ΔT1) was defined as percentual difference in T1-rest and T1-stress. Follow-up data were extracted from electronic patients records. In patients with recent coffee intake SSO was identified in 96%, which showed no significant difference with SSO in controls (94%, p = 0.835), however event rates were significantly different (13.6 and 0.8%, respectively (p < 0.001), median FU 17 months). Myocardial ΔT1 in the coffee group (− 5.2%) was significantly lower compared to control (+ 4.0%, p < 0.001), in contrast to the splenic ΔT1 (− 3.7 and − 4.0%, p = 0.789). The splenic T1-mapping results failed to predict false negative results. SSO and splenic rest-stress T1-mapping are not reliable indicators of stress adequacy in patients with recent coffee intake. Therefore, the dark spleen sign does not indicate adequate myocardial stress in patients with recent caffeine intake. Myocardial rest-stress T1-mapping is an excellent indicator of stress adequacy during adenosine perfusion CMR. Springer Netherlands 2017-11-24 2018 /pmc/articles/PMC5859139/ /pubmed/29177579 http://dx.doi.org/10.1007/s10554-017-1274-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Kuijpers, Dirkjan
van Dijk, Randy
van Assen, Marly
Kaandorp, Theodorus A. M.
van Dijkman, Paul R. M.
Vliegenthart, Rozemarijn
van der Harst, Pim
Oudkerk, Matthijs
Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake
title Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake
title_full Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake
title_fullStr Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake
title_full_unstemmed Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake
title_short Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake
title_sort disagreement between splenic switch-off and myocardial t1-mapping after caffeine intake
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859139/
https://www.ncbi.nlm.nih.gov/pubmed/29177579
http://dx.doi.org/10.1007/s10554-017-1274-0
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