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Dissection of the Role of VIMP in Endoplasmic Reticulum-Associated Degradation of CFTRΔF508
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is an important quality control mechanism that eliminates misfolded proteins from the ER. The Derlin-1/VCP/VIMP protein complex plays an essential role in ERAD. Although the roles of Derlin-1 and VCP are relatively clear, the functiona...
Autores principales: | Hou, Xia, Wei, Hongguang, Rajagopalan, Carthic, Jiang, Hong, Wu, Qingtian, Zaman, Khalequz, Xie, Youming, Sun, Fei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859151/ https://www.ncbi.nlm.nih.gov/pubmed/29555962 http://dx.doi.org/10.1038/s41598-018-23284-8 |
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