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Predator-secreted sulfolipids induce defensive responses in C. elegans
Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predato...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859177/ https://www.ncbi.nlm.nih.gov/pubmed/29555902 http://dx.doi.org/10.1038/s41467-018-03333-6 |
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author | Liu, Zheng Kariya, Maro J. Chute, Christopher D. Pribadi, Amy K. Leinwand, Sarah G. Tong, Ada Curran, Kevin P. Bose, Neelanjan Schroeder, Frank C. Srinivasan, Jagan Chalasani, Sreekanth H. |
author_facet | Liu, Zheng Kariya, Maro J. Chute, Christopher D. Pribadi, Amy K. Leinwand, Sarah G. Tong, Ada Curran, Kevin P. Bose, Neelanjan Schroeder, Frank C. Srinivasan, Jagan Chalasani, Sreekanth H. |
author_sort | Liu, Zheng |
collection | PubMed |
description | Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predator-specific molecular signature induces instantaneous escape behavior and a prolonged reduction in oviposition. Chemical analysis revealed this predator-specific signature to consist of a class of sulfolipids, produced by a biochemical pathway required for developing predacious behavior and specifically induced by starvation. These sulfolipids are detected by four pairs of C. elegans amphid sensory neurons that act redundantly and recruit cyclic nucleotide-gated (CNG) or transient receptor potential (TRP) channels to drive both escape and reduced oviposition. Functional homology of the delineated signaling pathways and abolishment of predator-evoked C. elegans responses by the anti-anxiety drug sertraline suggests a likely conserved or convergent strategy for managing predator threats. |
format | Online Article Text |
id | pubmed-5859177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58591772018-03-21 Predator-secreted sulfolipids induce defensive responses in C. elegans Liu, Zheng Kariya, Maro J. Chute, Christopher D. Pribadi, Amy K. Leinwand, Sarah G. Tong, Ada Curran, Kevin P. Bose, Neelanjan Schroeder, Frank C. Srinivasan, Jagan Chalasani, Sreekanth H. Nat Commun Article Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predator-specific molecular signature induces instantaneous escape behavior and a prolonged reduction in oviposition. Chemical analysis revealed this predator-specific signature to consist of a class of sulfolipids, produced by a biochemical pathway required for developing predacious behavior and specifically induced by starvation. These sulfolipids are detected by four pairs of C. elegans amphid sensory neurons that act redundantly and recruit cyclic nucleotide-gated (CNG) or transient receptor potential (TRP) channels to drive both escape and reduced oviposition. Functional homology of the delineated signaling pathways and abolishment of predator-evoked C. elegans responses by the anti-anxiety drug sertraline suggests a likely conserved or convergent strategy for managing predator threats. Nature Publishing Group UK 2018-03-19 /pmc/articles/PMC5859177/ /pubmed/29555902 http://dx.doi.org/10.1038/s41467-018-03333-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Liu, Zheng Kariya, Maro J. Chute, Christopher D. Pribadi, Amy K. Leinwand, Sarah G. Tong, Ada Curran, Kevin P. Bose, Neelanjan Schroeder, Frank C. Srinivasan, Jagan Chalasani, Sreekanth H. Predator-secreted sulfolipids induce defensive responses in C. elegans |
title | Predator-secreted sulfolipids induce defensive responses in C. elegans |
title_full | Predator-secreted sulfolipids induce defensive responses in C. elegans |
title_fullStr | Predator-secreted sulfolipids induce defensive responses in C. elegans |
title_full_unstemmed | Predator-secreted sulfolipids induce defensive responses in C. elegans |
title_short | Predator-secreted sulfolipids induce defensive responses in C. elegans |
title_sort | predator-secreted sulfolipids induce defensive responses in c. elegans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859177/ https://www.ncbi.nlm.nih.gov/pubmed/29555902 http://dx.doi.org/10.1038/s41467-018-03333-6 |
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