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Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline
Dementia and cognitive decline have become worldwide public health problems, and it was recently reported that life-style related diseases and obesity are key risk factors in dementia. Iso-α-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859182/ https://www.ncbi.nlm.nih.gov/pubmed/29555941 http://dx.doi.org/10.1038/s41598-018-23213-9 |
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author | Ayabe, Tatsuhiro Ohya, Rena Kondo, Keiji Ano, Yasuhisa |
author_facet | Ayabe, Tatsuhiro Ohya, Rena Kondo, Keiji Ano, Yasuhisa |
author_sort | Ayabe, Tatsuhiro |
collection | PubMed |
description | Dementia and cognitive decline have become worldwide public health problems, and it was recently reported that life-style related diseases and obesity are key risk factors in dementia. Iso-α-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via activation of peroxisome proliferator-activated receptor γ. In this report, we demonstrated that daily intake of iso-α-acids suppresses inflammations in the hippocampus and improves cognitive decline induced by high fat diet (HFD). Body weight, epididymal fat weight, and plasma triglyceride levels were increased in HFD-fed mice, and significantly decreased in iso-α-acids supplemented HFD-fed mice. HFD feeding enhances the production of inflammatory cytokines and chemokines, such as TNF-α, which was significantly suppressed by iso-α-acids administration. HFD-induced neuroinflammation caused lipid peroxidation, neuronal loss, and atrophy in hippocampus, and those were not observed in iso-α-acids-treated mice. Furthermore, iso-α-acids intake significantly improved cognitive decline induced by HFD-feeding. Iso-α-acids are food derived components that suppressing both lipid accumulation and brain inflammation, thus iso-α-acids might be beneficial for the risk of dementia increased by obesity and lifestyle-related diseases. |
format | Online Article Text |
id | pubmed-5859182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58591822018-03-20 Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline Ayabe, Tatsuhiro Ohya, Rena Kondo, Keiji Ano, Yasuhisa Sci Rep Article Dementia and cognitive decline have become worldwide public health problems, and it was recently reported that life-style related diseases and obesity are key risk factors in dementia. Iso-α-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via activation of peroxisome proliferator-activated receptor γ. In this report, we demonstrated that daily intake of iso-α-acids suppresses inflammations in the hippocampus and improves cognitive decline induced by high fat diet (HFD). Body weight, epididymal fat weight, and plasma triglyceride levels were increased in HFD-fed mice, and significantly decreased in iso-α-acids supplemented HFD-fed mice. HFD feeding enhances the production of inflammatory cytokines and chemokines, such as TNF-α, which was significantly suppressed by iso-α-acids administration. HFD-induced neuroinflammation caused lipid peroxidation, neuronal loss, and atrophy in hippocampus, and those were not observed in iso-α-acids-treated mice. Furthermore, iso-α-acids intake significantly improved cognitive decline induced by HFD-feeding. Iso-α-acids are food derived components that suppressing both lipid accumulation and brain inflammation, thus iso-α-acids might be beneficial for the risk of dementia increased by obesity and lifestyle-related diseases. Nature Publishing Group UK 2018-03-19 /pmc/articles/PMC5859182/ /pubmed/29555941 http://dx.doi.org/10.1038/s41598-018-23213-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ayabe, Tatsuhiro Ohya, Rena Kondo, Keiji Ano, Yasuhisa Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline |
title | Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline |
title_full | Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline |
title_fullStr | Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline |
title_full_unstemmed | Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline |
title_short | Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline |
title_sort | iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859182/ https://www.ncbi.nlm.nih.gov/pubmed/29555941 http://dx.doi.org/10.1038/s41598-018-23213-9 |
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