Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells

Scoulerine is an isoquinoline alkaloid, which indicated promising suppression of cancer cells growth. However, the mode of action (MOA) remained unclear. Cytotoxic and antiproliferative properties were determined in this study. Scoulerine reduces the mitochondrial dehydrogenases activity of the eval...

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Detalles Bibliográficos
Autores principales: Habartova, Klara, Havelek, Radim, Seifrtova, Martina, Kralovec, Karel, Cahlikova, Lucie, Chlebek, Jakub, Cermakova, Eva, Mazankova, Nadezda, Marikova, Jana, Kunes, Jiri, Novakova, Lucie, Rezacova, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859271/
https://www.ncbi.nlm.nih.gov/pubmed/29555944
http://dx.doi.org/10.1038/s41598-018-22862-0

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