Key genes and regulatory networks involved in the initiation, progression and invasion of colorectal cancer

AIM: Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC. RESULTS: The results of gene expres...

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Detalles Bibliográficos
Autores principales: Asghari, Matin, Abazari, Mohammad Foad, Bokharaei, Hanieh, Aleagha, Maryam Nouri, Poortahmasebi, Vahdat, Askari, Hassan, Torabinejad, Sepehr, Ardalan, Abbas, Negaresh, Navid, Ataei, Atousa, Pazooki, Parisa, Poorebrahim, Mansour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859335/
https://www.ncbi.nlm.nih.gov/pubmed/29568567
http://dx.doi.org/10.4155/fsoa-2017-0108
Descripción
Sumario:AIM: Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC. RESULTS: The results of gene expression profiles were integrated with protein–protein interaction networks, and topologically analyzed. The most important regulatory genes (e.g., CDK1, UBC, ESR1 and ATXN1) and signaling pathways (e.g., Wnt, MAPK and JAK-STAT) in CRC initiation, progression and metastasis were identified. In vitro analysis confirmed some in silico findings. CONCLUSION: Our study introduces functional hub genes, subnetworks, prioritizes signaling pathways and novel biomarkers in CRC that may guide further development of targeted therapy programs.

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