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Antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the Anthropocene

The contemporary Anthropocene is characterized by rapidly evolving complex global challenges to planetary health vis-a-vis sustainable development, yet innovation is constrained under the prevailing precautionary regime that regulates technological change. Small-molecule xenobiotic drugs are amenabl...

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Autor principal: Caoili, Salvador Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859341/
https://www.ncbi.nlm.nih.gov/pubmed/29568564
http://dx.doi.org/10.4155/fsoa-2017-0101
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author Caoili, Salvador Eugenio
author_facet Caoili, Salvador Eugenio
author_sort Caoili, Salvador Eugenio
collection PubMed
description The contemporary Anthropocene is characterized by rapidly evolving complex global challenges to planetary health vis-a-vis sustainable development, yet innovation is constrained under the prevailing precautionary regime that regulates technological change. Small-molecule xenobiotic drugs are amenable to efficient large-scale industrial synthesis; but their pharmacokinetics, pharmacodynamics, interactions and ultimate ecological impact are difficult to predict, raising concerns over initial testing and environmental contamination. Antibodies and similar agents can serve as antidotes and drug buffers or vehicles to address patient safety and decrease dosing requirements. More generally, peptidic agents including synthetic peptide-based constructs exemplified by vaccines can be used together with or instead of nonpeptidic xenobiotics, thus enabling advances in planetary health based on principles of green chemistry from manufacturing through final disposition.
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spelling pubmed-58593412018-03-22 Antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the Anthropocene Caoili, Salvador Eugenio Future Sci OA Special Report The contemporary Anthropocene is characterized by rapidly evolving complex global challenges to planetary health vis-a-vis sustainable development, yet innovation is constrained under the prevailing precautionary regime that regulates technological change. Small-molecule xenobiotic drugs are amenable to efficient large-scale industrial synthesis; but their pharmacokinetics, pharmacodynamics, interactions and ultimate ecological impact are difficult to predict, raising concerns over initial testing and environmental contamination. Antibodies and similar agents can serve as antidotes and drug buffers or vehicles to address patient safety and decrease dosing requirements. More generally, peptidic agents including synthetic peptide-based constructs exemplified by vaccines can be used together with or instead of nonpeptidic xenobiotics, thus enabling advances in planetary health based on principles of green chemistry from manufacturing through final disposition. Future Science Ltd 2018-01-10 /pmc/articles/PMC5859341/ /pubmed/29568564 http://dx.doi.org/10.4155/fsoa-2017-0101 Text en © 2018 Salvador Eugenio Caoili This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Special Report
Caoili, Salvador Eugenio
Antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the Anthropocene
title Antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the Anthropocene
title_full Antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the Anthropocene
title_fullStr Antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the Anthropocene
title_full_unstemmed Antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the Anthropocene
title_short Antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the Anthropocene
title_sort antibodies, synthetic peptides and related constructs for planetary health based on green chemistry in the anthropocene
topic Special Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859341/
https://www.ncbi.nlm.nih.gov/pubmed/29568564
http://dx.doi.org/10.4155/fsoa-2017-0101
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