Overall Downregulation of mRNAs and Enrichment of H3K4me3 Change Near Genome-Wide Association Study Signals in Systemic Lupus Erythematosus: Cell-Specific Effects

This study was designed to define gene expression and H3K4me3 histone modifications in T cells, B cells, and monocytes in systemic lupus erythematosus (SLE). Array studies of total peripheral blood mononuclear cells have demonstrated gene expression signatures related to neutrophils, interferon, and...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Shi, Lihua, Song, Li, Maurer, Kelly, Petri, Michele A., Sullivan, Kathleen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859352/
https://www.ncbi.nlm.nih.gov/pubmed/29593737
http://dx.doi.org/10.3389/fimmu.2018.00497

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