Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival

Chromosomal rearrangements are common in cancer. More than 50% occur in common fragile sites and disrupt tumor suppressors. However, such rearrangements are not known in gastric cancer. Here we report recurrent 18q2 breakpoints in 6 of 17 gastric cancer cell lines. The rearranged chromosome 18, t(9;...

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Detalles Bibliográficos
Autores principales: Leong, Siew Hong, Lwin, Kyaw Myo, Lee, Sze Sing, Ng, Wai Har, Ng, Kia Min, Tan, Soo Yong, Ng, Bee Ling, Carter, Nigel P., Tang, Carol, Lian Kon, Oi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859466/
https://www.ncbi.nlm.nih.gov/pubmed/29872697
http://dx.doi.org/10.1038/s41698-017-0012-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859466/
https://www.ncbi.nlm.nih.gov/pubmed/29872697
http://dx.doi.org/10.1038/s41698-017-0012-3

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