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The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome

BACKGROUND: The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women. METHODS: A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility cent...

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Autores principales: Tuncay, Gorkem, Karaer, Abdullah, İnci Coşkun, Ebru, Baloğlu, Demet, Tecellioğlu, Ayşe Nihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859715/
https://www.ncbi.nlm.nih.gov/pubmed/29558997
http://dx.doi.org/10.1186/s12905-018-0541-0
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author Tuncay, Gorkem
Karaer, Abdullah
İnci Coşkun, Ebru
Baloğlu, Demet
Tecellioğlu, Ayşe Nihan
author_facet Tuncay, Gorkem
Karaer, Abdullah
İnci Coşkun, Ebru
Baloğlu, Demet
Tecellioğlu, Ayşe Nihan
author_sort Tuncay, Gorkem
collection PubMed
description BACKGROUND: The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women. METHODS: A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38–2.49 mIU/Land 2.50–4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L). RESULTS: There was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79–3.53), 1.08 (95% CI: 0.09–13.1), and 1.79 (95% CI: 0.77–4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit–administration rate) between the two groups. CONCLUSIONS: Our findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes. TRIAL REGISTRATION: This study is retrospectively registered by Ethical Review Board at Inonu University in 19th December 2017; Ethics approval no is 2017–27-20.
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spelling pubmed-58597152018-03-22 The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome Tuncay, Gorkem Karaer, Abdullah İnci Coşkun, Ebru Baloğlu, Demet Tecellioğlu, Ayşe Nihan BMC Womens Health Research Article BACKGROUND: The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women. METHODS: A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38–2.49 mIU/Land 2.50–4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L). RESULTS: There was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79–3.53), 1.08 (95% CI: 0.09–13.1), and 1.79 (95% CI: 0.77–4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit–administration rate) between the two groups. CONCLUSIONS: Our findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes. TRIAL REGISTRATION: This study is retrospectively registered by Ethical Review Board at Inonu University in 19th December 2017; Ethics approval no is 2017–27-20. BioMed Central 2018-03-20 /pmc/articles/PMC5859715/ /pubmed/29558997 http://dx.doi.org/10.1186/s12905-018-0541-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Tuncay, Gorkem
Karaer, Abdullah
İnci Coşkun, Ebru
Baloğlu, Demet
Tecellioğlu, Ayşe Nihan
The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome
title The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome
title_full The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome
title_fullStr The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome
title_full_unstemmed The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome
title_short The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome
title_sort impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859715/
https://www.ncbi.nlm.nih.gov/pubmed/29558997
http://dx.doi.org/10.1186/s12905-018-0541-0
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