Transcription factor E2F3a regulates CASP8AP2 transcription and enhances sensitivity to chemotherapeutic drugs in acute lymphoblastic leukemia

BACKGROUND: Low expression of E2F3a and caspase 8 associated protein 2 (CASP8AP2) are associated with poor prognosis of childhood acute lymphoblastic leukemia (ALL). METHODS: Dual-luciferase reporter assay and wild type as well as four mutated types of reporter plasmids were used to demonstrate the...

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Detalles Bibliográficos
Autores principales: Liu, Fei-Fei, Wang, Kai-Ling, Deng, Li-Ping, Liu, Xiao, Wu, Min-yuan, Wang, Tian-You, Cui, Lei, Li, Zhi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859744/
https://www.ncbi.nlm.nih.gov/pubmed/29568235
http://dx.doi.org/10.1186/s12935-018-0531-1

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