Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide

BACKGROUND: Chimeric antigen receptors (CARs) presented on T cell surfaces enable redirection of T cell specificity, which has enormous promise in antitumor therapy. However, excessive activity and poor control over such engineered T cells cause significant safety challenges, such as cytokine releas...

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Detalles Bibliográficos
Autores principales: Zhang, Erhao, Gu, Jieyi, Xue, Jianpeng, Lin, Chenyu, Liu, Chen, Li, Mengwei, Hao, Jingchao, Setrerrahmane, Sarra, Chi, Xiaowei, Qi, Weiyan, Hu, Jialiang, Xu, Hanmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859748/
https://www.ncbi.nlm.nih.gov/pubmed/29558951
http://dx.doi.org/10.1186/s13045-018-0591-7

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