BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

B cells play a critical role in the immune response by producing antibodies, which display remarkable diversity. Here we describe a bioinformatic pipeline, BALDR (BCR Assignment of Lineage using De novo Reconstruction) that accurately reconstructs the paired heavy and light chain immunoglobulin gene...

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Detalles Bibliográficos
Autores principales: Upadhyay, Amit A., Kauffman, Robert C., Wolabaugh, Amber N., Cho, Alice, Patel, Nirav B., Reiss, Samantha M., Havenar-Daughton, Colin, Dawoud, Reem A., Tharp, Gregory K., Sanz, Iñaki, Pulendran, Bali, Crotty, Shane, Lee, F. Eun-Hyung, Wrammert, Jens, Bosinger, Steven E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859752/
https://www.ncbi.nlm.nih.gov/pubmed/29558968
http://dx.doi.org/10.1186/s13073-018-0528-3

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