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Protein tyrosine phosphatase PTPN22 regulates IL‐1β dependent Th17 responses by modulating dectin‐1 signaling in mice

A single nucleotide polymorphism within the PTPN22 gene is a strong genetic risk factor predisposing to the development of multiple autoimmune diseases. PTPN22 regulates Syk and Src family kinases downstream of immuno‐receptors. Fungal β‐glucan receptor dectin‐1 signals via Syk, and dectin‐1 stimula...

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Detalles Bibliográficos
Autores principales:	Purvis, Harriet A, Clarke, Fiona, Jordan, Christine K, Blanco, Cristina Sanchez, Cornish, Georgina H, Dai, Xuezhi, Rawlings, David J, Zamoyska, Rose, Cope, Andrew P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Immunodeficiencies and autoimmunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859948/ https://www.ncbi.nlm.nih.gov/pubmed/28948613 http://dx.doi.org/10.1002/eji.201747092

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