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Neuronal regulation of longevity by staying cool
Aging is fundamental to life and reflects functional declines in different tissues at the organismal level. As a systematic process, aging can be influenced by the interplay between genetic and environmental factors, and the nervous system plays a crucial role in this regulation. Environmental input...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859961/ https://www.ncbi.nlm.nih.gov/pubmed/29491133 http://dx.doi.org/10.1101/gad.312405.118 |
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author | Lin, Chih-Chun J. Neve, Isaiah A.A. Wang, Meng C. |
author_facet | Lin, Chih-Chun J. Neve, Isaiah A.A. Wang, Meng C. |
author_sort | Lin, Chih-Chun J. |
collection | PubMed |
description | Aging is fundamental to life and reflects functional declines in different tissues at the organismal level. As a systematic process, aging can be influenced by the interplay between genetic and environmental factors, and the nervous system plays a crucial role in this regulation. Environmental inputs can be sensed by the nervous system, which consequently triggers signaling outputs toward peripheral tissues to regulate gene expression systematically. Thus, understanding the underlying molecular mechanisms behind environmentally triggered neuron–periphery cross-talk is crucial for the promotion of an organism's health and longevity. |
format | Online Article Text |
id | pubmed-5859961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58599612018-08-01 Neuronal regulation of longevity by staying cool Lin, Chih-Chun J. Neve, Isaiah A.A. Wang, Meng C. Genes Dev Outlook Aging is fundamental to life and reflects functional declines in different tissues at the organismal level. As a systematic process, aging can be influenced by the interplay between genetic and environmental factors, and the nervous system plays a crucial role in this regulation. Environmental inputs can be sensed by the nervous system, which consequently triggers signaling outputs toward peripheral tissues to regulate gene expression systematically. Thus, understanding the underlying molecular mechanisms behind environmentally triggered neuron–periphery cross-talk is crucial for the promotion of an organism's health and longevity. Cold Spring Harbor Laboratory Press 2018-02-01 /pmc/articles/PMC5859961/ /pubmed/29491133 http://dx.doi.org/10.1101/gad.312405.118 Text en © 2018 Lin et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Outlook Lin, Chih-Chun J. Neve, Isaiah A.A. Wang, Meng C. Neuronal regulation of longevity by staying cool |
title | Neuronal regulation of longevity by staying cool |
title_full | Neuronal regulation of longevity by staying cool |
title_fullStr | Neuronal regulation of longevity by staying cool |
title_full_unstemmed | Neuronal regulation of longevity by staying cool |
title_short | Neuronal regulation of longevity by staying cool |
title_sort | neuronal regulation of longevity by staying cool |
topic | Outlook |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859961/ https://www.ncbi.nlm.nih.gov/pubmed/29491133 http://dx.doi.org/10.1101/gad.312405.118 |
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