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Neuronal regulation of longevity by staying cool

Aging is fundamental to life and reflects functional declines in different tissues at the organismal level. As a systematic process, aging can be influenced by the interplay between genetic and environmental factors, and the nervous system plays a crucial role in this regulation. Environmental input...

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Detalles Bibliográficos
Autores principales: Lin, Chih-Chun J., Neve, Isaiah A.A., Wang, Meng C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859961/
https://www.ncbi.nlm.nih.gov/pubmed/29491133
http://dx.doi.org/10.1101/gad.312405.118
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author Lin, Chih-Chun J.
Neve, Isaiah A.A.
Wang, Meng C.
author_facet Lin, Chih-Chun J.
Neve, Isaiah A.A.
Wang, Meng C.
author_sort Lin, Chih-Chun J.
collection PubMed
description Aging is fundamental to life and reflects functional declines in different tissues at the organismal level. As a systematic process, aging can be influenced by the interplay between genetic and environmental factors, and the nervous system plays a crucial role in this regulation. Environmental inputs can be sensed by the nervous system, which consequently triggers signaling outputs toward peripheral tissues to regulate gene expression systematically. Thus, understanding the underlying molecular mechanisms behind environmentally triggered neuron–periphery cross-talk is crucial for the promotion of an organism's health and longevity.
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spelling pubmed-58599612018-08-01 Neuronal regulation of longevity by staying cool Lin, Chih-Chun J. Neve, Isaiah A.A. Wang, Meng C. Genes Dev Outlook Aging is fundamental to life and reflects functional declines in different tissues at the organismal level. As a systematic process, aging can be influenced by the interplay between genetic and environmental factors, and the nervous system plays a crucial role in this regulation. Environmental inputs can be sensed by the nervous system, which consequently triggers signaling outputs toward peripheral tissues to regulate gene expression systematically. Thus, understanding the underlying molecular mechanisms behind environmentally triggered neuron–periphery cross-talk is crucial for the promotion of an organism's health and longevity. Cold Spring Harbor Laboratory Press 2018-02-01 /pmc/articles/PMC5859961/ /pubmed/29491133 http://dx.doi.org/10.1101/gad.312405.118 Text en © 2018 Lin et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Lin, Chih-Chun J.
Neve, Isaiah A.A.
Wang, Meng C.
Neuronal regulation of longevity by staying cool
title Neuronal regulation of longevity by staying cool
title_full Neuronal regulation of longevity by staying cool
title_fullStr Neuronal regulation of longevity by staying cool
title_full_unstemmed Neuronal regulation of longevity by staying cool
title_short Neuronal regulation of longevity by staying cool
title_sort neuronal regulation of longevity by staying cool
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859961/
https://www.ncbi.nlm.nih.gov/pubmed/29491133
http://dx.doi.org/10.1101/gad.312405.118
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