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A rADAR defense against RNAi

Adenosine deaminases that act on RNA (ADARs) convert adenosines (A) to inosines (I) in stretches of dsRNA. The biological purpose of these editing events for the vast majority of ADAR substrates is largely unknown. In this issue of Genes & Development, Reich and colleagues (pp. 271–282) demonstr...

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Detalles Bibliográficos
Autor principal: Pasquinelli, Amy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859962/
https://www.ncbi.nlm.nih.gov/pubmed/29491134
http://dx.doi.org/10.1101/gad.313049.118
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author Pasquinelli, Amy E.
author_facet Pasquinelli, Amy E.
author_sort Pasquinelli, Amy E.
collection PubMed
description Adenosine deaminases that act on RNA (ADARs) convert adenosines (A) to inosines (I) in stretches of dsRNA. The biological purpose of these editing events for the vast majority of ADAR substrates is largely unknown. In this issue of Genes & Development, Reich and colleagues (pp. 271–282) demonstrate that in Caenorhabditis elegans, A-to-I editing in double-stranded regions of protein-coding transcripts protects these RNAs from targeting by the RNAi pathway. Disruption of this safeguard through loss of ADAR activity coupled with enhanced RNAi results in developmental abnormalities and profound changes in gene expression that suggest aberrant induction of an antiviral response. Thus, editing of cellular dsRNA by ADAR helps prevent host RNA silencing and inadvertent antiviral activity.
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spelling pubmed-58599622018-08-01 A rADAR defense against RNAi Pasquinelli, Amy E. Genes Dev Outlook Adenosine deaminases that act on RNA (ADARs) convert adenosines (A) to inosines (I) in stretches of dsRNA. The biological purpose of these editing events for the vast majority of ADAR substrates is largely unknown. In this issue of Genes & Development, Reich and colleagues (pp. 271–282) demonstrate that in Caenorhabditis elegans, A-to-I editing in double-stranded regions of protein-coding transcripts protects these RNAs from targeting by the RNAi pathway. Disruption of this safeguard through loss of ADAR activity coupled with enhanced RNAi results in developmental abnormalities and profound changes in gene expression that suggest aberrant induction of an antiviral response. Thus, editing of cellular dsRNA by ADAR helps prevent host RNA silencing and inadvertent antiviral activity. Cold Spring Harbor Laboratory Press 2018-02-01 /pmc/articles/PMC5859962/ /pubmed/29491134 http://dx.doi.org/10.1101/gad.313049.118 Text en © 2018 Pasquinelli; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Pasquinelli, Amy E.
A rADAR defense against RNAi
title A rADAR defense against RNAi
title_full A rADAR defense against RNAi
title_fullStr A rADAR defense against RNAi
title_full_unstemmed A rADAR defense against RNAi
title_short A rADAR defense against RNAi
title_sort radar defense against rnai
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859962/
https://www.ncbi.nlm.nih.gov/pubmed/29491134
http://dx.doi.org/10.1101/gad.313049.118
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