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A rADAR defense against RNAi
Adenosine deaminases that act on RNA (ADARs) convert adenosines (A) to inosines (I) in stretches of dsRNA. The biological purpose of these editing events for the vast majority of ADAR substrates is largely unknown. In this issue of Genes & Development, Reich and colleagues (pp. 271–282) demonstr...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859962/ https://www.ncbi.nlm.nih.gov/pubmed/29491134 http://dx.doi.org/10.1101/gad.313049.118 |
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author | Pasquinelli, Amy E. |
author_facet | Pasquinelli, Amy E. |
author_sort | Pasquinelli, Amy E. |
collection | PubMed |
description | Adenosine deaminases that act on RNA (ADARs) convert adenosines (A) to inosines (I) in stretches of dsRNA. The biological purpose of these editing events for the vast majority of ADAR substrates is largely unknown. In this issue of Genes & Development, Reich and colleagues (pp. 271–282) demonstrate that in Caenorhabditis elegans, A-to-I editing in double-stranded regions of protein-coding transcripts protects these RNAs from targeting by the RNAi pathway. Disruption of this safeguard through loss of ADAR activity coupled with enhanced RNAi results in developmental abnormalities and profound changes in gene expression that suggest aberrant induction of an antiviral response. Thus, editing of cellular dsRNA by ADAR helps prevent host RNA silencing and inadvertent antiviral activity. |
format | Online Article Text |
id | pubmed-5859962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58599622018-08-01 A rADAR defense against RNAi Pasquinelli, Amy E. Genes Dev Outlook Adenosine deaminases that act on RNA (ADARs) convert adenosines (A) to inosines (I) in stretches of dsRNA. The biological purpose of these editing events for the vast majority of ADAR substrates is largely unknown. In this issue of Genes & Development, Reich and colleagues (pp. 271–282) demonstrate that in Caenorhabditis elegans, A-to-I editing in double-stranded regions of protein-coding transcripts protects these RNAs from targeting by the RNAi pathway. Disruption of this safeguard through loss of ADAR activity coupled with enhanced RNAi results in developmental abnormalities and profound changes in gene expression that suggest aberrant induction of an antiviral response. Thus, editing of cellular dsRNA by ADAR helps prevent host RNA silencing and inadvertent antiviral activity. Cold Spring Harbor Laboratory Press 2018-02-01 /pmc/articles/PMC5859962/ /pubmed/29491134 http://dx.doi.org/10.1101/gad.313049.118 Text en © 2018 Pasquinelli; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Outlook Pasquinelli, Amy E. A rADAR defense against RNAi |
title | A rADAR defense against RNAi |
title_full | A rADAR defense against RNAi |
title_fullStr | A rADAR defense against RNAi |
title_full_unstemmed | A rADAR defense against RNAi |
title_short | A rADAR defense against RNAi |
title_sort | radar defense against rnai |
topic | Outlook |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859962/ https://www.ncbi.nlm.nih.gov/pubmed/29491134 http://dx.doi.org/10.1101/gad.313049.118 |
work_keys_str_mv | AT pasquinelliamye aradardefenseagainstrnai AT pasquinelliamye radardefenseagainstrnai |